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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Objective : To investigate the effects of the SLCO1B1 A388G polymorphism on the lipid-lowering efficacy and myotoxicity incidence of statins, a systematic review and meta-analysis was conducted. Methods : The databases of PubMed, Embase, Ovid, and Cochrane Library were searched for all published studies from inception to April 2018. Using the Review Manager 5, the pooled estimates of the weighted mean difference (WMD) of the percent changes of low-density lipoprotein cholesterol (LDL-C), odds ratio (OR) and corresponding 95 % confidence intervals (CIs) were calculated. Results : A total of 12 observational studies were included in the meta-analysis of the lipid-lowering efficacy of statins. The pooled analysis showed no significant association between SLCO1B1 A388G polymorphism and LDL-C reduction (AG+GG vs AA, WMD: -0.38, 95% CI: -3.00, 2.24, p=0.77). However, in the subgroup analysis of the subjects with baseline LDL-C levels of at least 160 mg/dL, the 388G allele was significantly associated with a greater reduction in LDL-C (GG vs AA+AG, WMD: -1.78, 95% CI: - 3.12, -0.44, p=0.009; AG+GG vs AA, WMD: -2.89, 95% CI: -4.96, -0.81, p=0.006; GG vs AA, WMD: - 4.32, 95% CI: -6.93, -1.72, p=0.001). Four observational studies were eligible for meta-analysis of statin-induced myotoxicity incidence. The pooled analysis showed that SLCO1B1 A388G polymorphism was not associated with the incidence of statin-induced myotoxicity (GG vs AA, OR: 0.95, 95% CI: 0.80, 1.12, p=0.52). Conclusions : The SLCO1B1 388G allele was significantly associated with a greater reduction in LDL-C following statin therapy in the subjects with baseline LDL-C levels of at least 160 mg/dL. This result suggests that genotyping SLCO1B1 A388G polymorphism prior to statin therapy may be useful to predict an individual’s dose and potential to achieve target LDL-C levels, especially in patients with high baseline LDL-C levels.
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참고문헌 (59)
참고문헌 신청
van Rooy MJ / 2014 / Obesity, hypertension and hypercholesterolemia as risk factors for atherosclerosis leading to ischemic events / Curr Med Chem 21(19):2121~2129
Last AR / 2017 / Hyperlipidemia : Drugs for Cardiovascular Risk Reduction in Adults / Am Fam Physician 95(2):78~87
Committee for the Korean Guidelines for the Management of Dyslipidemia / 2016 / 2015 Korean Guidelines for the Management of Dyslipidemia: Executive Summary (English Translation) / Korean Circulation Journal 46(3):275~306
Korean Statistical Information Service
Korea Informative Classification of Diseases / Disease statistics
Last AR / 2017 / Hyperlipidemia : Drugs for Cardiovascular Risk Reduction in Adults / Am Fam Physician 95(2):78~87
Committee for the Korean Guidelines for the Management of Dyslipidemia / 2016 / 2015 Korean Guidelines for the Management of Dyslipidemia: Executive Summary (English Translation) / Korean Circulation Journal 46(3):275~306
Korean Statistical Information Service
Korea Informative Classification of Diseases / Disease statistics
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