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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제3호
- 발행연도
- 2020.1
- 수록면
- 448 - 458 (11page)
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We investigated the therapeutic effects of microRNA-139-5p in relation to osteoporosis of bone marrow-derived mesenchymal stem cell (BMSCs) and its underlying mechanisms. In this study we used a dexamethasone-induced in vivo model of osteoporosis and BMSCs were used for the in vitro model. Real-time quantitative polymerase chain reaction (RT-PCR) and gene chip were used to analyze the expression of microRNA-139-5p. In an osteoporosis rat model, the expression of microRNA-139-5p was increased, compared with normal group. Downregulation of microRNA-139-5p promotes cell proliferation and osteogenic differentiation in BMSCs. Especially, up-regulation of microRNA-139-5p reduced cell proliferation and osteogenic differentiation in BMSCs. Overexpression of miR-139-5p induced Wnt/β-catenin and down-regulated NOTCH1 signaling in BMSCs. Down-regulation of miR-139-5p suppressed Wnt/β-catenin and induced NOTCH1 signaling in BMSCs. The inhibition of NOTCH1 reduced the effects of anti-miR-139-5p on cell proliferation and osteogenic differentiation in BMSCs. Activation of Wnt/β-catenin also inhibited the effects of anti-miR-139-5p on cell proliferation and osteogenic differentiation in BMSCs. Taken together, our results suggested that the inhibition of microRNA-139-5p promotes osteogenic differentiation of BMSCs via targeting Wnt/β-catenin signaling pathway by NOTCH1.
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참고문헌 (27)
참고문헌 신청
Liu H / 2016 / Development of marker genes for jasmonic acid signaling in shoots and roots of wheat / Plant Signal Behav 11:e1176654
Nagato AC / 2015 / Hyperoxia promotes polarization of the immune response in ovalbumin-induced airway inflammation, leading to a TH17 cell phenotype / Immun. Inflamm. Dis 3:321~337
Saric A / 2015 / Diminished resistance to hyperoxia in brains of reproductively senescent female CBA/H mice / Med. Sci. Monit. Basic Res 21:191~199
Cong J / 2016 / MiR-634decreases cell proliferation and induces apoptosis by targeting mTOR signaling pathway in cervical cancer cells / Artif. Cells Nanomed. Biotechnol 44:1694~1701
Cui X / 2016 / Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1 / Sci. Rep 6:23117
Nagato AC / 2015 / Hyperoxia promotes polarization of the immune response in ovalbumin-induced airway inflammation, leading to a TH17 cell phenotype / Immun. Inflamm. Dis 3:321~337
Saric A / 2015 / Diminished resistance to hyperoxia in brains of reproductively senescent female CBA/H mice / Med. Sci. Monit. Basic Res 21:191~199
Cong J / 2016 / MiR-634decreases cell proliferation and induces apoptosis by targeting mTOR signaling pathway in cervical cancer cells / Artif. Cells Nanomed. Biotechnol 44:1694~1701
Cui X / 2016 / Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1 / Sci. Rep 6:23117
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