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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 573 - 585 (13page)
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Purpose Lymphoblastic lymphoma (LBL) is an invasive neoplasm of precursor T-cell or B-cell lineage. A broadly accepted standard treatment for adult LBL has not yet been defined. Materials and Methods To address this issue, we compared two chemotherapy regimens: a modified non-Hodgkin lymphoma Berlin–Frankfurt–Mu!nster-95 (NHL-BFM-95) regimen and HyperCVAD/MA. This retrospective study consecutively enrolled 207 adult LBL patients at two hospitals from 2000 to 2018. Univariate and multivariate analysis were used to assess prognostic factors. Results In the present study, most clinical characteristics were similar between the two treatment groups except for age and lactate dehydrogenase (LDH) level. Patients treated with modified NHL-BFM-95 regimen tended to be younger and with elevated LDH level. The modified NHLBFM- 95 regimen produced better treatment outcomes than those with HyperCVAD/MA in patients with T-LBL or patients < 40 years. Treatment with HyperCVAD/MA, high Eastern Cooperative Oncology Group scores, and bone marrow involvement were independent risk factors in T-LBL. No patients interrupted treatment for severe adverse events. Conclusion The results suggested that the modified regimen is well-tolerated and can produce the promising outcomes in patients with T-LBL or patients < 40 years.
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참고문헌 (27)
참고문헌 신청
Bassan R / 2016 / Lymphoblastic lymphoma : an updated review on biology, diagnosis, and treatment / Eur J Haematol 96:447~460
Cortelazzo S / 2017 / Lymphoblastic lymphoma / Crit Rev Oncol Hematol 113:304~317
Nathwani BN / 1981 / Lymphoblastic lymphoma : a clinicopathologic study of 95 patients / Cancer 48:2347~2357
Jost LM / 1995 / Short-term weekly chemotherapy followed by high-dose therapy with autologous bone marrow transplantation for lymphoblastic and Burkitt's lymphomas in adult patients / Ann Oncol 6:445~451
Le Gouill S / 2003 / Adult lymphoblastic lymphoma : a retrospective analysis of 92 patients under 61 years included in the LNH87/93 trials / Leukemia 17:2220~2224
Cortelazzo S / 2017 / Lymphoblastic lymphoma / Crit Rev Oncol Hematol 113:304~317
Nathwani BN / 1981 / Lymphoblastic lymphoma : a clinicopathologic study of 95 patients / Cancer 48:2347~2357
Jost LM / 1995 / Short-term weekly chemotherapy followed by high-dose therapy with autologous bone marrow transplantation for lymphoblastic and Burkitt's lymphomas in adult patients / Ann Oncol 6:445~451
Le Gouill S / 2003 / Adult lymphoblastic lymphoma : a retrospective analysis of 92 patients under 61 years included in the LNH87/93 trials / Leukemia 17:2220~2224
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