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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 187 - 192 (6page)
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BackgroundThis study aimed to assess the treatment outcomes of ifosphamide, mesna, etoposide, and prednisolone (IMEP) combination regimen as a front-line chemotherapy in patients with peripheral T-cell lymphomas (PTCLs).MethodsClinical data of 38 newly diagnosed PTCLs patients who underwent IMEP at Busan Paik Hospital from January 2002 to December 2013 were retrospectively analyzed. ResultsThe overall response rate was 68.5%, with 21 (55.3%) complete response/complete re-sponse unconfirmed and 6 (15.8%) partial response (PR). The median follow-up duration was 25.5 months (range, 0.2‒87.3). The median overall survival was not reached and 2-year survival rate was 67%. The median progression free survival was 23 months. The most frequently reported adverse effects higher than grade 3 were hematologic toxicities including neutropenia (68.4%), thrombocytopenia (42.1%). There was no treat-ment-related mortality.ConclusionIMEP regimen is effective and safe as a front-line chemotherapy in patients with PTCLs.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Armitage JO / 2013 / The aggressive peripheral T-cell lymphomas: 2013 / Am J Hematol 88:910~918
김진만 / 2011 / WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study / Journal of Pathology and Translational Medicine 45(3):254~260
Vose J / 2008 / International peripheral T-cell and natural killer/T-cell lymphoma study: Pathology findings and clinical outcomes / J Clin Oncol 26:4124~4130
Gisselbrecht C / 1998 / Prognostic significance of T-cell phenotype in aggressive non-hodgkin's lymphomas. Groupe d'etudes des lymphomes de l'adulte (GELA) / Blood 92:76~82
Cabanillas F / 1982 / IMVP-16:An effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy / Blood 60:693~697
김진만 / 2011 / WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study / Journal of Pathology and Translational Medicine 45(3):254~260
Vose J / 2008 / International peripheral T-cell and natural killer/T-cell lymphoma study: Pathology findings and clinical outcomes / J Clin Oncol 26:4124~4130
Gisselbrecht C / 1998 / Prognostic significance of T-cell phenotype in aggressive non-hodgkin's lymphomas. Groupe d'etudes des lymphomes de l'adulte (GELA) / Blood 92:76~82
Cabanillas F / 1982 / IMVP-16:An effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy / Blood 60:693~697
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