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학술저널
저자정보
Tang, YuJiao (Division of Food Bio Science, College of Biomedical and Health Sciences, Konkuk University) Jeon, Byong-Tae (Division of Food Bio Science, College of Biomedical and Health Sciences, Konkuk University) Wang, Yanmei (Jilin Sino-Rok Institute of Animal Science) Choi, Eun-Ju (Division of Sport Science, College of Biomedical and Health Sciences, Konkuk University) Kim, Yon-Suk (Department of Biotechnology, Konkuk University) Hwang, Jin-Woo (Department of Biotechnology, Konkuk University) Park, Pyo-Jam (Korea Nokyong Research Center, Konkuk University) Moon, Sang Ho (Division of Food Bio Science, College of Biomedical and Health Sciences, Konkuk University) Kim, Eun-Kyung (Division of Food Bio Science, College of Biomedical and Health Sciences, Konkuk University)
저널정보
한국축산식품학회 한국축산식품학회지 한국축산식품학회지 제35권 제4호
발행연도
2015.1
수록면
507 - 514 (8page)

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Deer velvet antler (DVA) is one of the most popular medicines in China. Numerous studies have demonstrated that velvet antler possess biological effects. However, data regarding its anti-migration activity on prostate cancer is scarce. In this study, we investigated the inhibitory effect of top DVA (T-DVA) on the expression of prostate-specific antigen (PSA) and migration-related genes in the human prostate cancer cell, LNCaP. The T-DVA down-regulated the expression of PSA. In addition, the Radius<sup>TM</sup> assay revealed that T-DVA inhibited the migration behavior of prostate cancer cells. Furthermore, the expression of matrix metalloproteinase (MMP)-9 and vascular endothelial growth factor (VEGF) was also decreased with T-DVA. On the contrary, T-DVA increased the tissue inhibition of metallo-proteinase (TIMP)-1 and (TIMP)-2. Taken together, our findings indicate that the T-DVA possesses anti-migration activity on prostate cancer cells. This is the first study of DVA to report the anti-migration activity on prostate cancer.

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