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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 208 - 208 (1page)
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초록· 키워드
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Mitophagy, a selective degradation of damaged mitochondria, plays a central role in maintaining mitochondria quality control. Previous studies showed a decrease in mitophagy activity is closely related to neurodegenerative diseases including Alzheimer’s disease. Increasing mitophagy is now considered a promising strategy for the treatment of neurodegenerative diseases. However, mitophagy inducer that is effective enough to treat disease and has low toxicity is very limited. Using previously developed mitophagy assay system and single compound library from medicinal plants, we have identified isoquinoline alkaloid PA17 as a mitophagy inducers. Through chemical optimization, we developed CD1-012 that is tens of times more active in promoting mitophagy activity. CD1-012 treatment was not induced a collapse of mitochondria membrane potential and an increase of mitochondrial ROS level, indicating that CD1-012 is not act as mitochondria toxin. In addition, analysis o ... 전체 초록 보기
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