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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 953 - 963 (11page)
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초록· 키워드
오류제보하기
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an infectious disease with multiple severe symptoms, such as fever over 37.5°C, cough, dyspnea, and pneumonia. In our research, microRNAs (miRNAs) binding to the genome sequences of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory-related coronavirus (MERS-CoV), and SARS-CoV-2 were identified by bioinformatic tools. Five miRNAs (hsa-miR-15a-5p, hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-16-5p, and hsa-miR-196a-1-3p) were found to commonly bind to SARS-CoV, MERS-CoV, and SARS-CoV-2. We also identified miRNAs that bind to receptor proteins, such as ACE2, ADAM17, and TMPRSS2, which are important for understanding the infection mechanism of SARS-CoV-2. The expression patterns of those miRNAs were examined in hamster lung samples infected by SARS-CoV-2. Five miRNAs (hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-221-3p, hsa-miR-140-3p, and hsa-miR-422a) showed differential expression patterns in lung tissues before and after infection. Especially, hsa-miR-15b-5p and hsa-miR-195-5p showed a large difference in expression, indicating that they may potentially be diagnostic biomarkers for SARS-CoV-2 infection.
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참고문헌 (84)
참고문헌 신청
Abdel-Mohsen, M. / 2014 / Role of microRNA modulation in the interferon-α/ribavirin suppression of HIV-1in vivo / PLoS One 9:e109220
Anderson, G. / 2020 / Melatonin : roles in influenza, Covid-19, and other viral infections / Rev. Med. Virol 30:e2109
Aqeilan, R. / 2010 / miR-15a and miR-16-1 in cancer : discovery, function and future perspectives / Cell Death Differ 17:215~220
Ashour, H. M. / 2020 / Insights into the recent 2019 novel coronavirus(SARS-CoV-2)in light of past human coronavirus outbreaks / Pathogens 9:186
Bandi, N. / 2009 / miR-15a and miR-16are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non–small cell lung cancer / Cancer Res 69:5553~5559
Anderson, G. / 2020 / Melatonin : roles in influenza, Covid-19, and other viral infections / Rev. Med. Virol 30:e2109
Aqeilan, R. / 2010 / miR-15a and miR-16-1 in cancer : discovery, function and future perspectives / Cell Death Differ 17:215~220
Ashour, H. M. / 2020 / Insights into the recent 2019 novel coronavirus(SARS-CoV-2)in light of past human coronavirus outbreaks / Pathogens 9:186
Bandi, N. / 2009 / miR-15a and miR-16are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non–small cell lung cancer / Cancer Res 69:5553~5559
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