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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제7호
- 발행연도
- 2020.1
- 수록면
- 1,044 - 1,050 (7page)
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Abelmoschus manihot (Linn.) is a medicinal herbal plant that is commonly used to treat chronic kidney disease and hepatitis. However, its effect on cell proliferation has not been clearly revealed. In this report, we sought to determine the effect of the flower extract of A. manihot (FA) on cell proliferation. Based on our findings, FA increased the proliferation of human diploid fibroblast (HDF) and HEK293 cells. Through cell cycle analysis, FA was found to increase the number of HDF cells in the S phase and G2/M phase. FA also increased the expression of cyclin D1 and enhanced the migration of HDF cells. By administering FA to HDF cells with ≥30 passages, a decrease in the number of senescence-associated β galactosidase-positive cells was observed, thereby indicating that FA can ameliorate cellular senescence. Collectively, our findings indicate that FA increases cyclin D1 expression and regulates cell proliferation.
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참고문헌 (19)
참고문헌 신청
Yang Z / 2018 / Enrichment and purification of the bioactive flavonoids from flower of Abelmoschus manihot (L.) medic using macroporous resins / Molecules 23:2649
Zheng X / 2016 / Identification and characterization of a cytotoxic polysaccharide from the flower of Abelmoschus manihot / Int. J. Biol. Macromol 82:284~290
Xue C / 2011 / Identification of the potential active components of Abelmoscth ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry / J. Chromatogr. B Analyt. Technol. Biomed. Life Sci 879:317~325
Lei Zhou / 2012 / Pretreatment with the Total Flavone Glycosides of Flos Abelmoschus manihot and Hyperoside Prevents Glomerular Podocyte Apoptosis in Streptozotocin-Induced Diabetic Nephropathy / Journal of Medicinal Food 15(5):461~468
Yan JY / 2015 / Investigations of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats / J. Ethnopharmacol. 172:202~213
Zheng X / 2016 / Identification and characterization of a cytotoxic polysaccharide from the flower of Abelmoschus manihot / Int. J. Biol. Macromol 82:284~290
Xue C / 2011 / Identification of the potential active components of Abelmoscth ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry / J. Chromatogr. B Analyt. Technol. Biomed. Life Sci 879:317~325
Lei Zhou / 2012 / Pretreatment with the Total Flavone Glycosides of Flos Abelmoschus manihot and Hyperoside Prevents Glomerular Podocyte Apoptosis in Streptozotocin-Induced Diabetic Nephropathy / Journal of Medicinal Food 15(5):461~468
Yan JY / 2015 / Investigations of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats / J. Ethnopharmacol. 172:202~213
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