지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 126 - 133 (8page)
이용수
초록· 키워드
오류제보하기
Homer proteins are scaffold proteins that regulate calcium (Ca2+) signaling by modulating the activity of multiple Ca2+signaling proteins. In our previous report, Homer2 and Homer3 regulated NFATc1 function through its interactionwith calcineurin, which then acted to regulate receptor activator of nuclear factor-kappa B ligand (RANKL)-inducedosteoclastogenesis and bone metabolism. However, to date, the role of Homers in osteoclastogenesis remainsunknown. In this study, we investigated the roles of Homer2 and Homer3 in aging-dependent bone remodeling. Deletion of Homer2 /Homer3 (Homer2/3 DKO) markedly decreased the bone density of the femur. The decrease inbone density was not seen in mice with Homer2 (Homer2?/?) and Homer3 (Homer3?/?) deletion. Moreover, RANKLtreatment of bone marrow-derived monocytes/macrophages in Homer2/3 DKO mice significantly increased theformation of multinucleated cells and resorption areas. Finally, Homer2/3 DKO mice decreased bone density in anaging-dependent manner. These findings suggest a novel potent mode of bone homeostasis regulation throughosteoclasts differentiation during aging by Homer proteins, specifically Homer2 and Homer3.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
U.H. Lerner / 2006 / Bone Remodeling in Post-menopausal Osteoporosis / Journal of Dental Research 85(7):584~595
H. TAKAYANAGI / 2007 / The Role of NFAT in Osteoclast Formation / Annals of the New York Academy of Sciences 1116(1):227~237
Mone Zaidi / 2007 / Skeletal remodeling in health and disease / Nature Medicine 13(7):791~801
Hiroshi Takayanagi / 2002 / Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts / Developmental Cell 3(6):889~901
Xiang Luo / 2001 / RGS Proteins Provide Biochemical Control of Agonist-Evoked [Ca2+]i Oscillations / Molecular Cell 7(3):651~660
H. TAKAYANAGI / 2007 / The Role of NFAT in Osteoclast Formation / Annals of the New York Academy of Sciences 1116(1):227~237
Mone Zaidi / 2007 / Skeletal remodeling in health and disease / Nature Medicine 13(7):791~801
Hiroshi Takayanagi / 2002 / Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts / Developmental Cell 3(6):889~901
Xiang Luo / 2001 / RGS Proteins Provide Biochemical Control of Agonist-Evoked [Ca2+]i Oscillations / Molecular Cell 7(3):651~660
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Regulatory mechanisms of the store-operated Ca2+ entry through Orai1 and STIM1 by an adaptor protein in non-excitable cells
International Journal of Oral Biology
2022 .09
-
Regulation of the expression and function of TRPCs and Orai1 by Homer2 in mouse pancreatic acinar cells
International Journal of Oral Biology
2021 .09
-
Reviewing not Homer’s Iliad, but “Kai Bao Ben Cao”: indigo dye—the past, present, and future
Intestinal research
2023 .04
-
Homer2 regulates amylase secretion via physiological calcium oscillations in mouse parotid gland acinar cells
International Journal of Oral Biology
2020 .01
-
Acer tegmentosum Maxim Prevents Bone Loss by Inhibiting Osteoclastogenesis and Promoting Osteoblast Mineralization in Ovariectomized Mice
Natural Product Sciences
2020 .03
-
The Time Course Changes in Bone Metabolic Markers after Administering the Anti-Receptor Activator of Nuclear Factor-Kappa B Ligand Antibody and Drug Compliance among Patients with Osteoporosis
Asian Spine Journal
2015 .01
-
Titanium Mesh for Bone Augmentation in Oral Implant Surgery
대한구강악안면임플란트학회지
2021 .12
-
Bone modeling, remodeling, and skeletal health in children and adolescents: mineral accrual, assessment and treatment
Annals of Pediatirc Endocrinology & Metabolism
2017 .01
-
Bone defect model in animals for evaluation of bone grafts
한국실험동물학회 학술발표대회 논문집
2016 .02
-
갑상선자극호르몬이 골대사에 미치는 영향
International Journal of Thyroidology
2016 .01
-
CCR5 deficiency in aged mice causes a decrease in bone mass
International Journal of Oral Biology
2019 .01
-
Assessment of bone density changes following two-jaw surgery using multidetector computed tomography: A pilot study
대한치과교정학회지
2020 .05
-
Pro-inflammatory Cytokines Modulating Osteoclast Differentiation and Function
대한류마티스학회지
2016 .01
-
The effects of spinal cord injury on bone loss and dysregulation of the calcium/parathyroid hormone loop in mice
Osteoporosis and Sarcopenia
2016 .01
-
Updates on Paget’s Disease of Bone
Endocrinology and Metabolism
2022 .10
-
골 대체물 및 골 치유 촉진에 대한 발전
대한골절학회지
2017 .01
-
Factors associated with Advanced Bone Age in Overweight and Obese Children
Pediatric Gastroenterology, Hepatology & Nutrition
2020 .01
-
Bio-structural monitoring of bone mineral alterations through electromechanical impedance measurements of a Piezo-device joined to a tooth
Biomedical Engineering Letters (BMEL)
2020 .01
-
Bone morbidity in pediatric acute lymphoblastic leukemia
Annals of Pediatirc Endocrinology & Metabolism
2020 .01
-
Vertical Ridge Augmentation with Mandibular Ramus Block Bone for Implant Surgery
대한구강악안면임플란트학회지
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0