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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 260 - 269 (10page)
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Background: Umbilical cord-mesenchymal stem cell-conditioned medium (UC-MSC-CM) has emerged as a promising cell-free therapy. The aim of this study was to explore the therapeutic effects of UC-MSC-CM on insulin resistance in C2C12 cell. Methods: Insulin resistance was induced by palmitate. Effects of UC-MSC-CM on insulin resistance were evaluated using glucose uptake, glucose transporter type 4 (GLUT4) translocation, the insulin-signaling pathway, and mitochondrial contents and functions in C2C12 cell. Results: Glucose uptake was improved by UC-MSC-CM. UC-MSC-CM treatment increased only in membranous GLUT4 expression, not in cytosolic GLUT4 expression. It restored the insulin-signaling pathway in insulin receptor substrate 1 and protein kinase B. Mitochondrial contents evaluated by mitochondrial transcription factor A, mitochondrial DNA copy number, and peroxisome proliferator-activated receptor gamma coactivator 1-alpha were increased by UC-MSC-CM. In addition, UC-MSC-CM significantly decreased mitochondrial reactive oxygen species and increased fatty acid oxidation and mitochondrial membrane potential. There was no improvement in adenosine triphosphate (ATP) contents, but ATP synthesis was improved by UC-MSCCM. Cytokine and active factor analysis of UC-MSC-CM showed that it contained many regulators inhibiting insulin resistance. Conclusion: UC-MSC-CM improves insulin resistance with multiple mechanisms in C2C12 cell.
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참고문헌 (39)
참고문헌 신청
안용호 / 2018 / A Journey to Understand Glucose Homeostasis: Starting from Rat Glucose Transporter Type 2 Promoter Cloning to Hyperglycemia / Diabetes and Metabolism Journal 42(6):465~471
곽수헌 / 2018 / Pathophysiology of Type 2 Diabetes in Koreans / Endocrinology and Metabolism 33(1):9~16
김경수 / 2019 / Nonalcoholic Fatty Liver Disease and Diabetes: Part II: Treatment / Diabetes and Metabolism Journal 43(2):127~143
American Diabetes Association / 2019 / 6. Glycemic targets : standards of medical care in diabetes. 2019 / Diabetes Care 42(Suppl 1):S61~70
고승현 / 2018 / Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis / Diabetes and Metabolism Journal 42(2):93~100
곽수헌 / 2018 / Pathophysiology of Type 2 Diabetes in Koreans / Endocrinology and Metabolism 33(1):9~16
김경수 / 2019 / Nonalcoholic Fatty Liver Disease and Diabetes: Part II: Treatment / Diabetes and Metabolism Journal 43(2):127~143
American Diabetes Association / 2019 / 6. Glycemic targets : standards of medical care in diabetes. 2019 / Diabetes Care 42(Suppl 1):S61~70
고승현 / 2018 / Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis / Diabetes and Metabolism Journal 42(2):93~100
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