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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한응급의학회 Clinical and Experimental Emergency Medicine Clinical and Experimental Emergency Medicine Vol.6 No.1
- 발행연도
- 2019.1
- 수록면
- 49 - 63 (15page)
이용수
초록· 키워드
오류제보하기
Objective To investigate the epidemiology of sepsis in Korea and identify risk factors for death in sepsis. Methods We conducted a longitudinal, population-based epidemiological study of sepsis in Korea from 2005 to 2012 using the National Health Insurance Service-National Sample Cohort, a population-based cohort representing 2.2% of the Korean population. The primary objective was to assess the incidence, mortality and cost of sepsis. The secondary objective was to identify the risk factors for death in sepsis. Claim records of admitted adult patients (aged ≥15 years) were analyzed. Sepsis was defined as 1) bacterial or fungal infection or the conditions they often complicate, 2) prescription of intravenous antibiotics, and 3) presence of any organ dysfunction. Comorbidities were defined using the Charlson/Deyo method. Risk factors for 6-month mortality were assessed using multivariable logistic regression. Results A total of 22,882 cases were identified. Both incidence and 6-month mortality increased from 265.7 (95% confidence interval [CI], 254.7 to 277.1) to 453.1 (95% CI, 439.0 to 467.5) per 100,000 person-years (P-trend <0.001) and from 26.5% (95% CI, 24.4% to 28.8%) to 30.1% (95% CI, 28.4% to 31.9%), respectively. After standardization, the increasing trend of incidence was slower but still significant (P-trend <0.001), while that for mortality was not (P-trend 0.883). The average cost increased by 75.5% (P-trend <0.001). Multivariable logistic regression identified various risk factors for mortality. Conclusion The burden of sepsis in Korea was high and is expected to increase considering the aging population. Proactive measures to curtail this increase should be sought and implemented.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Singer M / 2016 / The third international consensus definitions for sepsis and septic shock (Sepsis-3) / JAMA 315:801~810
Vincent JL / 2014 / Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit / Lancet Respir Med 2:380~386
Rhodes A / 2016 / Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 / Intensive Care Med 43:304~377
Martin GS / 2003 / The epidemiology of sepsis in the United States from 1979 through 2000 / N Engl J Med 348:1546~1554
Williams MD / 2004 / Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care / Crit Care 8:R291~R298
Vincent JL / 2014 / Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit / Lancet Respir Med 2:380~386
Rhodes A / 2016 / Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 / Intensive Care Med 43:304~377
Martin GS / 2003 / The epidemiology of sepsis in the United States from 1979 through 2000 / N Engl J Med 348:1546~1554
Williams MD / 2004 / Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care / Crit Care 8:R291~R298
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