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논문 기본 정보

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학술저널
저자정보
Balaram Krishna J Hanumanthu (Mount Sinai Beth Israel Hospital New York NY USA) Anika Sasidharan Nair (Jacobi Medical Center Albert Einstein College of Medicine New York NY USA) Adarsh Katamreddy (Jacobi Medical Center Albert Einstein College of Medicine New York NY USA) Jason S Gilbert (Albert Einstein College of Medicine Bronx NY USA) Jee Young You (Jacobi Medical Center Albert Einstein College of Medicine New York NY USA) Obiageli Lynda Offor (Jacobi Medical Center Albert Einstein College of Medicine New York NY USA) Ankit Kushwaha (Jacobi Medical Center Albert Einstein College of Medicine New York NY USA) Ankita Krishnan (Jacobi Medical Center Albert Einstein College of Medicine New York NY USA) Marzio Napolitano (Jacobi Medical Center Albert Einstein College of Medicine New York NY USA) Leonidas Palaidimos (Jacobi Medical Center Albert Einstein College of Medicine New York NY USA) Joaquin Morante (Jacobi Medical Center Albert Einstein College of Medicine New York NY USA) Seema S. Tekwani (Emory University School of Medicine Atlanta GA USA) Suchita Mehta (Institute of Critical Care Medicine Mount Sinai Hospital New York NY USA) Aanchal Gupta (Division of Pulmonary and Critical Care Medicine Beth Israel Lahey Health Burlington MA USA) Harmeen Goraya (University of Arkansas for Medical Sciences Medical Center) Mengyang Sun (Department of Obstetrics and Gynecology Jacobi Medical Center Albert Einstein College of Medicine) Robert T. Faillace (Jacobi Medical Center Albert Einstein College of Medicine New York NY USA) Perminder Gulani (Jacobi Medical Center Albert Einstein College of Medicine New York NY USA)
저널정보
대한중환자의학회 Acute and Critical Care Acute and Critical Care 제36권 제3호
발행연도
2021.8
수록면
215 - 222 (8page)
DOI
10.4266/acc.2021.00234

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Background Patients with sepsis are at risk for developing sepsis-induced cardiomyopathy (SIC). Previous studies offer inconsistent results regarding the association of SIC and mortality. This study sought to assess whether SIC is linked to mortality in patients with sepsis and to evaluate predictors of the development of SIC. Methods In this retrospective study, patients admitted to the medical intensive care unit with a diagnosis of sepsis in the absence of acute coronary syndrome were included. SIC was identified using transthoracic echo and was defined by a new onset decline in left ventricular ejection fraction (LVEF) ≤50%, or ≥10% decline in LVEF compared to baseline in patients with a history of heart failure with reduced ejection fraction. Multivariable logistic regression analysis was performed using the R software program. Results Of the 359 patients in the final analysis, 19 (5.3%) had SIC. Eight (42.1%) of the 19 patients in the SIC group and 60 (17.6%) of the 340 patients in the non-SIC group died during hospitalization. SIC was associated with an increased risk for all-cause in-hospital mortality (odds ratio [OR], 4.46; 95% confidence interval [CI], 1.15?18.69; P=0.03). Independent predictors for the development of SIC were albumin level (OR, 0.47; 95% CI, 0.23?0.93; P=0.03) and culture positivity (OR, 8.47; 95% CI, 2.24?55.61; P=0.006). Concomitant right ventricular hypokinesis was noted in 13 (68.4%) of the 19 SIC patients. Conclusions SIC was associated with an increased risk for all-cause in-hospital mortality. Low albumin level and culture positivity were independent predictors of SIC.
#cardiomyopathy #mortality #sepsis #septic shock.

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참고문헌 (22)

참고문헌 신청
Singer M / 2016 / The third international consensus definitions for sepsis and septic shock(Sepsis-3) / JAMA 315:801~810 google schola Angus DC / 2013 / Severe sepsis and septic shock / N Engl J Med 369:840~851 google schola Parker MM / 1984 / Profound but reversible myocardial depression in patients with septic shock / Ann Intern Med 100:483~490 google schola L’Heureux M / 2020 / Sepsis-induced cardiomyopathy : a comprehensive review / Curr Cardiol Rep 22:35 google schola Landesberg G / 2012 / Diastolic dysfunction and mortality in severe sepsis and septic shock / Eur Heart J 33:895~903 google schola

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