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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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In recent years, epidemiological studies, genome-wide association studies, and Mendelian randomization studies have shown a strong association between increased levels of lipoproteins and increased risks of coronary heart disease and cardiovascular disease (CVD). Although lipoprotein(a) [Lp(a)] was an independent risk factor for ASCVD, the latest international clinical guidelines do not recommend direct reduction of plasma Lp(a) concentrations. The main reason was that there is no effective clinical medicine that directly lowers plasma Lp(a) concentrations. However, recent clinical trials have shown that proprotein convertase subtilisin/kexin-type 9 inhibitors (PCSK9) and second-generation antisense oligonucleotides can effectively reduce plasma Lp(a) levels. This review will present the structure, pathogenicity, prognostic evidences, and recent advances in therapeutic drugs for Lp(a).
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참고문헌 (83)
참고문헌 신청
Scandinavian Simvastatin Survival Study G / 1994 / Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease : the Scandinavian Simvastatin Survival Study(4S) / Lancet 344:1383~1389
Sacks FM / 1996 / The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators / N Engl J Med 335:1001~1009
Downs JR / 1998 / Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study / JAMA 279:1615~1622
Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group / 1998 / Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels / N Engl J Med 339:1349~1357
Cannon CP / 2004 / Intensive versus moderate lipid lowering with statins after acute coronary syndromes / N Engl J Med 350:1495~1504
Sacks FM / 1996 / The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators / N Engl J Med 335:1001~1009
Downs JR / 1998 / Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study / JAMA 279:1615~1622
Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group / 1998 / Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels / N Engl J Med 339:1349~1357
Cannon CP / 2004 / Intensive versus moderate lipid lowering with statins after acute coronary syndromes / N Engl J Med 350:1495~1504
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