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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 117 - 125 (9page)
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Objectives: The effects of obesity on thyroid function have not been well established. The aim of this study was to investigate the effects of body mass index (BMI) and/or non-alcoholic fatty liver disease (NAFLD) on thyroid function. Methods: A retrospective longitudinal analysis was conducted among subjects who underwent comprehensive health check-ups at least four times between 2008 and 2017. Thyroid function was investigated according to BMI or presence of NAFLD at the end of follow-up. The subjects were divided into four groups: control (n = 216), subjects with obese (n = 94), subjects with NAFLD (n = 48), and subjects with obese + NAFLD (n = 93). Obesity was defined as BMI ≥ 25 kg/m². Results: During the mean follow-up of 6.8 years (6.8 ± 1.2 years), 42 of the 451 subjects (9.3%) had subclinical hypothyroidism (SCH) but no subjects developed overt hypothyroidism. In multivariate Cox proportional hazard analysis, after adjustment for age, sex, smoking, and baseline thyroid stimulating hormone level, obese subjects with NAFLD had a higher risk of SCH than the control group. Conclusions: The obese subjects with NAFLD had a higher risk for SCH in the future.
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참고문헌 (19)
참고문헌 신청
Bedogni G / 2005 / Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study / Hepatology 42:44~52
Lazo M / 2008 / The epidemiology of nonalcoholic fatty liver disease: a global perspective / Semin Liver Dis 28:339~350
Chung GE / 2012 / Non-alcoholic fatty liver disease across the spectrum of hypothyroidism / J Hepatol 57:150~156
Sanyal D / 2016 / Hypothyroidism and obesity: An intriguing link / Indian J Endocrinol Metab 20:554~557
Knudsen N / 2005 / Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population / J Clin Endocrinol Metab 90:4019~4024
Lazo M / 2008 / The epidemiology of nonalcoholic fatty liver disease: a global perspective / Semin Liver Dis 28:339~350
Chung GE / 2012 / Non-alcoholic fatty liver disease across the spectrum of hypothyroidism / J Hepatol 57:150~156
Sanyal D / 2016 / Hypothyroidism and obesity: An intriguing link / Indian J Endocrinol Metab 20:554~557
Knudsen N / 2005 / Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population / J Clin Endocrinol Metab 90:4019~4024
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