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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 188 - 196 (9page)
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Objective. This study examined the anti-inflammatory and chondroprotective effects of compound K (CK), a ginsenoside metabolite, on chondrocytes from osteoarthritis (OA) patients following stimulation with interleukin (IL)-1β. Methods. Articular cartilage samples were obtained from six OA patients undergoing total knee replacement surgery. Nitric oxide (NO) production was measured by the Griess reaction. Subsequently, the mRNA and protein levels of matrix metalloproteinases (MMPs), inducible NO synthase (iNOS), and mitogen-activated protein kinases (MAPKs) were examined by a reverse transcription-polymerase chain reaction and western blot analysis. Cartilage degradation was assessed using a glycosaminoglycan (GAG) assay. Results. CK inhibited IL-1β-induced NO production and iNOS expression in a dose-dependent manner. In addition, it inhibited the IL-1β-stimulated release of MMP-1, -3, and -13 and tissue inhibitor of matrix metalloproteinase-1 from OA patient chondrocytes. In addition, CK effectively suppressed the IL-1β-induced phosphorylation of p38, extracellular signal-regulated kinase-1/2, and c-Jun N-terminal kinase MAPKs. Moreover, the IL-1β-mediated release of GAG was inhibited by CK in a dose-dependent manner. Conclusion. CK inhibited the IL-1β-induced expression of inflammatory mediators and MMPs by, at least in part, inhibiting MAPK activation, and has potential as a therapeutic agent for the treatment of OA.
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참고문헌 (40)
참고문헌 신청
Centers for Disease Control and Prevention / 2010 / Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation --- United States, 2007-2009 / MMWR Morb Mortal Wkly Rep 59:1261~1265
Liu-Bryan R / 2015 / Inflammation and intracellular metabolism: new targets in OA / Osteoarthritis Cartilage 23:1835~1842
Loeser RF / 2012 / Osteoarthritis: a disease of the joint as an organ / Arthritis Rheum 64:1697~1707
Melchiorri C / 1998 / Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis / Arthritis Rheum 41:2165~2174
Farahat MN / 1993 / Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis / Ann Rheum Dis 52:870~875
Liu-Bryan R / 2015 / Inflammation and intracellular metabolism: new targets in OA / Osteoarthritis Cartilage 23:1835~1842
Loeser RF / 2012 / Osteoarthritis: a disease of the joint as an organ / Arthritis Rheum 64:1697~1707
Melchiorri C / 1998 / Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis / Arthritis Rheum 41:2165~2174
Farahat MN / 1993 / Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis / Ann Rheum Dis 52:870~875
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