지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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The protein kinase CK2α (formerly Casein Kinase II) is implicated in tumorigenesis and transformation. However, the mechanisms of CK2α activation in breast cancer have yet to be elucidated. This study investigated the mechanisms of CK2α activation in estrogen signaling. Estrogen increased reactive oxygen species (ROS) production, CK2α activity, and protein expression in estrogen receptor positive (ER+) MCF-7 human breast cancer cells, which were inhibited by the antioxidant N-acetyl-L-cysteine. H2O2 enhanced CK2α activity and protein expression. Human epidermal growth factor (EGF) increased ROS production, CK2α activity and protein expression in EGF receptor 2 (HER2)-overexpressing MCF-7(MCF-7 HER2) cells, but not in MCF-7 cells. Estrogen induced the phosphorylation of p38 mitogen-activated protein kinase (MAPK). The p38 inhibitor, SB202190, blocked estrogen-induced increases in ROS production, CK2α activity and CK2α protein expression. The data suggest that ROS/p38 MAPK is the key inducer of CK2α activation in response to estrogen or EGF.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (41)
참고문헌 신청
Allende JE / 1995 / Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation / FASEB Journal 9:313~323
Bae YS / 1997 / Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation / Journal of Biological Chemistry 272:217~221
Brennan JP / 2006 / Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation / Journal of Biological Chemistry 281:21827~21836
Burness ML / 2010 / Epidermal growth factor receptor in triplenegative and basal-like breast cancer: promising clinical target or only a marker / Cancer Journal 16:23~32
Carew JS / 2002 / Mitochondrial defects in cancer / Molecular Cancer 1:15
Bae YS / 1997 / Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation / Journal of Biological Chemistry 272:217~221
Brennan JP / 2006 / Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation / Journal of Biological Chemistry 281:21827~21836
Burness ML / 2010 / Epidermal growth factor receptor in triplenegative and basal-like breast cancer: promising clinical target or only a marker / Cancer Journal 16:23~32
Carew JS / 2002 / Mitochondrial defects in cancer / Molecular Cancer 1:15
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UCI(KEPA) : I410-ECN-0101-2019-510-000546467