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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 154 - 166 (13page)
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Although several ginsenosides have been reported to have anti-arthritic activity, few in vivo studies of the anti-arthritic effects of compound K (CK), a major metabolite of ginsenosides, have been conducted. Therefore, we investigated the preventative and therapeutic effects of CK on collagen-induced arthritis (CIA). Methods. CK was administered to CIA mice preventively and therapeutically and post-treatment bone microarchitectural characteristics, histopathological changes, and serum levels of anti-collagen antibodies, tumor necrosis factor-α, and interleukin (IL)-17 were investigated. We also examined cytokine production by type II collagen (CII)-stimulated splenocytes and mRNA expression of matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinase (TIMP)-1, receptor activator of nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG) in the joint tissues. Results. CK reduced the severity of CIA preventively and therapeutically (all p＜0.05). Additionally, CK dose-dependently decreased histopathological signs of arthritis and improved microarchitectural characteristics (all p ＜0.05) at 10 to 20 mg/kg/d in CIA mice. CK treatment significantly decreased the serum levels of anti-CII immunoglobulin G (p＜0.01) and the secretion of interferon-γ and IL-2 from stimulated splenocytes (all p＜0.05). Furthermore, MMP-3/TIMP-1 and RANKL/OPG ratios were suppressed in CK treated mice (all p＜0.01). Conclusion. CK attenuated CIA via suppression of the humoral immune response and modulation of joint-destructive mediators. These results suggest that CK has therapeutic potential in rheumatoid arthritis
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참고문헌 (41)
참고문헌 신청
Furneri G. / 2012 / Systematic literature review on economic implications and pharmacoeconomic issues of rheumatoid arthritis / Clin Exp Rheumatol 30(4 Suppl 73):S72~S84
Smolen JS. / 2010 / Treating rheumatoid arthritis to target : recommendations of an in ternational task force / Ann Rheum Dis 69:631~637
정영옥 / 2012 / Recent Paradigm Shifts in the Diagnosis and Treatment of Rheumatoid Arthritis / The Korean Journal of Internal Medicine 27(4):378~387
Moreland L. / 2005 / Unmet needs in rheumatoid arthritis / Arthritis Res Ther 7(Suppl 3):S2~S8
Kim HA. / 2007 / Anti-arthritic effect of ginsenoside Rb1 on collagen induced arthritis in mice / Int Immunopharmacol 7:1286~1291
Smolen JS. / 2010 / Treating rheumatoid arthritis to target : recommendations of an in ternational task force / Ann Rheum Dis 69:631~637
정영옥 / 2012 / Recent Paradigm Shifts in the Diagnosis and Treatment of Rheumatoid Arthritis / The Korean Journal of Internal Medicine 27(4):378~387
Moreland L. / 2005 / Unmet needs in rheumatoid arthritis / Arthritis Res Ther 7(Suppl 3):S2~S8
Kim HA. / 2007 / Anti-arthritic effect of ginsenoside Rb1 on collagen induced arthritis in mice / Int Immunopharmacol 7:1286~1291
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