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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 500 - 504 (5page)
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초록· 키워드
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Nonalcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver, occurring when fat is accumulated in the liver withoutalcohol consumption. NAFLD is the most common liver disorder in advanced countries. NAFLD is a spectrum of pathology involvinghepatic steatosis with/without inflammation and nonalcoholic steatohepatitis with accumulation of hepatocyte damage and hepaticfibrosis. Recent studies have revealed that NAFLD results in the progression of cryptogenic cirrhosis that leads to hepatocarcinomaand cardiovascular diseases such as heart failure. The main causes of NAFLD have not been revealed yet, metabolic syndromesincluding obesity and insulin resistance are widely accepted for the critical risk factors for the pathogenesis of NAFLD. Nuclearreceptors (NRs) are transcriptional factors that sense environmental or hormonal signals and regulate expression of genes, involvedin cellular growth, development, and metabolism. Several NRs have been reported to regulate genes involved in energy andxenobiotic metabolism and inflammation. Among various NRs, farnesoid X receptor (FXR) is abundantly expressed in the liver anda key regulator to control various metabolic processes in the liver. Recent studies have shown that NAFLD is associated with inappropriatefunction of FXR. The impact of FXR transcriptional activity in NAFLD is likely to be potential therapeutic strategy, butstill requires to elucidate underlying potent therapeutic mechanisms of FXR for the treatment of NAFLD. This article will focus thephysiological roles of FXR and establish the correlation between FXR transcriptional activity and the pathogenesis of NAFLD.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Williams CD / 2011 / Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy:a prospective study / Gastroenterology 140:124~131
Lazo M / 2013 / Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994 / Am J Epidemiol 178:38~45
Bonapace S / 2014 / Nonalcoholic fatty liver disease is associated with aortic valve sclerosis in patients with type 2 diabetes mellitus / PLoS One 9:e88371
El Azeem HA / 2013 / Association between nonalcoholic fatty liver disease and the incidence of cardiovascular and renal events / J Saudi Heart Assoc 25:239~246
Lin XF / 2014 / Increased risk of colorectal malignant neoplasm in patients with nonalcoholic fatty liver disease: a large study / Mol Biol Rep 41:2989~2997
Lazo M / 2013 / Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994 / Am J Epidemiol 178:38~45
Bonapace S / 2014 / Nonalcoholic fatty liver disease is associated with aortic valve sclerosis in patients with type 2 diabetes mellitus / PLoS One 9:e88371
El Azeem HA / 2013 / Association between nonalcoholic fatty liver disease and the incidence of cardiovascular and renal events / J Saudi Heart Assoc 25:239~246
Lin XF / 2014 / Increased risk of colorectal malignant neoplasm in patients with nonalcoholic fatty liver disease: a large study / Mol Biol Rep 41:2989~2997
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