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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 296 - 307 (12page)
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초록· 키워드
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Background: Insulin resistance is a major pathogenic hallmark of impaired glucose metabolism. We assessed the accuracy of insulin resistance and cut-off values using homeostasis model assessment of insulin resistance (HOMA-IR) to classify type 2 diabetes mellitus (T2DM) and dysglycemia according to age and sex. Methods: In this cross-sectional study, we analyzed 4,291 anti-diabetic drug-naïve adults (≥20 years) from the 6th Korea National Health and Nutrition Examination Survey in 2015. Metabolic syndrome (MetS) was defined by the modified National Cholesterol Education Program III guideline. Diagnosis of dysglycemia and T2DM were based on fasting glucose and glycosylated hemoglobin levels. The receiver operating characteristic curve and optimal cut-off values of HOMA-IR were assessed to identify T2DM/dysglycemia according to sex and were further analyzed by age. Results: Sex differences were found in the association of MetS and the different MetS components with T2DM/dysglycemia. The overall optimal cut-off value of HOMA-IR for identifying dysglycemia was 1.6 in both sex. The cut-off values for T2DM were 2.87 in men and 2.36 in women. However, there are differences in diagnostic range of HOMA-IR to distinguish T2DM according to sex and age, and the accuracy of HOMA-IR in identifying T2DM gradually decreased with age especially in women. Conclusion: Insulin resistance is closely associated with the risk for T2DM/dysglycemia. The accuracy of HOMA-IR levels is characterized by sex- and age-specific differences in identifying T2DM. In addition to insulin resistance index, insulin secretory function, and different MetS components should be considered in the detection of early T2DM, especially in elderly.
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참고문헌 (34)
참고문헌 신청
Abdul-Ghani MA / 2006 / Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose / Diabetes Care 29:1130~1139
노정현 / 2016 / The Diabetes Epidemic in Korea / Endocrinology and Metabolism 31(3):349~353
Danaei G / 2011 / National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants / Lancet 378:31~40
Kodama K / 2013 / Ethnic differences in the relationship between insulin sensitivity and insulin response: a systematic review and meta-analysis / Diabetes Care 36:1789~1796
Ohn JH / 2016 / 10-Year trajectory of $\beta$ -cell function and insulin sensitivity in the development of type 2 diabetes: a community-based prospective cohort study / Lancet Diabetes Endocrinol 4:27~34
노정현 / 2016 / The Diabetes Epidemic in Korea / Endocrinology and Metabolism 31(3):349~353
Danaei G / 2011 / National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants / Lancet 378:31~40
Kodama K / 2013 / Ethnic differences in the relationship between insulin sensitivity and insulin response: a systematic review and meta-analysis / Diabetes Care 36:1789~1796
Ohn JH / 2016 / 10-Year trajectory of
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