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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.68 No.4
- 발행연도
- 2015.1
- 수록면
- 364 - 372 (9page)
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초록· 키워드
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Background: Hydroxyethyl starch (HES) solutions are used as plasma expanders for correcting hypovolemia, but can lead to impaired coagulation. We evaluated the changes in hematological and hemostatic profiles with three types of HES. Methods: Patients were randomized to receive volume replacement with 10% pentastarch 260/0.45 in 0.9% saline (Group-PEN, n = 25), 6% tetrastarch 130/0.4 in 0.9% saline (Group-TETS, n = 25), or 6% tetrastarch 130/0.4 in a balanced electrolyte solution (Group-TETB, n = 25). Coagulation was assessed using rotational thromboelastometry (ROTEMⓇ) and other laboratory tests were performed, including measurements of hematological and hemostatic parameters and electrolytes. Results: Post-operative ROTEMⓇ parameters changed toward hypocoagulable states in all groups. The post-operative parameters of EXTEM and FIBTEM were more impaired in Group-PEN than in Group-TETB. The percentage change in INTEM clot formation time (P = 0.004) and α-angle (P = 0.003) were smaller in Group-TETS and Group-TETB than in Group-PEN. The percentage change in the FIBTEM maximum clot firmness was greatest in Group-PEN (P = 0.011). The international normalized ratio of prothrombin time (P < 0.001) and the activated partial thromboplastin time (P < 0.001) were significantly prolonged in Group-PEN compared to those of Group-TETB. Conclusions: The 6% HES 130/0.4 in a balanced electrolyte solution seemed to have less of an impact on blood coagulation than the 10% HES 260/0.45. No differences in hemostatic profile were observed between the balanced electrolyte and saline-based 6% HES 130/0.4.
목차
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참고문헌 (22)
참고문헌 신청
Eubanks JD. / 2010 / Antifibrinolytics in major orthopaedic surgery / J Am Acad Orthop Surg 18:132~138
Stanworth SJ / 2002 / Which groups of patients are transfused? A study of red cell usage in London and southeast England / Vox Sang 83:352~357
Gan TJ / 1999 / Hextend, a physiologically balanced plasma expander for large volume use in major surgery : a randomized phase III clinical trial. Hextend Study Group / Anesth Analg 88:992~998
Martin G / 2002 / A prospective, randomized comparison of thromboelastographic coagulation profile in patients receiving lactated Ringer’s solution, 6% hetastarch in a balanced-saline vehicle, or 6%hetastarch in saline during major surgery / J Cardiothorac Vasc Anesth 16:441~446
Mutter TC / 2013 / Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function :7
Stanworth SJ / 2002 / Which groups of patients are transfused? A study of red cell usage in London and southeast England / Vox Sang 83:352~357
Gan TJ / 1999 / Hextend, a physiologically balanced plasma expander for large volume use in major surgery : a randomized phase III clinical trial. Hextend Study Group / Anesth Analg 88:992~998
Martin G / 2002 / A prospective, randomized comparison of thromboelastographic coagulation profile in patients receiving lactated Ringer’s solution, 6% hetastarch in a balanced-saline vehicle, or 6%hetastarch in saline during major surgery / J Cardiothorac Vasc Anesth 16:441~446
Mutter TC / 2013 / Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function :7
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