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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 20 - 27 (8page)
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초록· 키워드
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Background: Anemia is a major risk factor that contributes to mortality in patientswith chronic kidney disease. There is controversy over the optimal hemoglobin (Hb)target in these patients. This study investigated the association between Hb leveland mortality in a cohort of hemodialysis (HD) patients in Korea.
Methods: This study was a multicenter prospective observational study of maintenanceHD patients that was performed for 5 years in western Seoul, Korea. Threehundred and sixty-two participants were enrolled. Laboratory values and mortalitywere accessed every 6 months. Repeated measures of laboratory values in eachinterval were averaged to obtain one semiannual mean value. The Hb values weredivided into six groups: (1) Hbo9 g/dL; (2) 9 g/dLrHbo10 g/dL; (3) 10 g/dLrHbo11 g/dL; (4) 11 g/dLrHbo12 g/dL; (5) 12 g/dLrHbo13 g/dL; and (6)HbZ13 g/dL. We analyzed the odds ratio for all-cause mortality, based on the Hbgroup, and adjusted for demographics and various laboratory values. Statistics wereperformed with SAS, version 9.1 software (SAS Institute Inc., Cary, NC, USA).
Results: Mortality odds ratios relative to the reference group (10–11 g/dL) in the fullyadjusted model were 3.61 foro9 g/dL; 3.17 for 9–10 g/dLn; 4.65 for 11–12 g/dLn; 5.50for 12–13 g/dLn; and 2.05 forZ13 g/dL (n indicates Po0.05).
Conclusion: In this study, a Hb level of 10–11 g/dL was associated with the lowestmortality among the groups with Hb levelo13 g/dL. Larger interventional trials arewarranted to determine the optimal Hb target for Korean HD patients.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Levin A / 1999 / Left ventricular mass index increase in early renal disease : impact of decline in hemoglobin / Am J Kidney Dis 34:125~134
Ma JZ / 1999 / Hematocrit level and associated mortality in hemodialysis patients / J Am Soc Nephrol 10:610~619
Ofsthun N / 2003 / The effects of higher hemoglobin levels on mortality and hospitalization in hemodialysis patients / Kidney Int 63:1908~1914
Parfrey PS / 2005 / Double-blind comparison of full and partial anemia correction in incident hemodialysis patients without symptomatic heart disease / J Am Soc Nephrol 16:2180~2189
Locatelli F / 2004 / Anemia management for hemodialysis patients : Kidney Disease Outcomes Quality Initiative(K/DOQI)guidelines and Dialysis Outcomes and Practice Patterns Study(DOPPS)findings / Am J Kidney Dis 44:27~33
Ma JZ / 1999 / Hematocrit level and associated mortality in hemodialysis patients / J Am Soc Nephrol 10:610~619
Ofsthun N / 2003 / The effects of higher hemoglobin levels on mortality and hospitalization in hemodialysis patients / Kidney Int 63:1908~1914
Parfrey PS / 2005 / Double-blind comparison of full and partial anemia correction in incident hemodialysis patients without symptomatic heart disease / J Am Soc Nephrol 16:2180~2189
Locatelli F / 2004 / Anemia management for hemodialysis patients : Kidney Disease Outcomes Quality Initiative(K/DOQI)guidelines and Dialysis Outcomes and Practice Patterns Study(DOPPS)findings / Am J Kidney Dis 44:27~33
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