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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 40 - 45 (6page)
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BackgroundThe expression of the SOCS genes in cytomegalovirus (CMV) viremia after hematopoieticstem cell transplantation (HSCT) remains largely unexplored. MethodsUsing quantitative RT-PCR of mononuclear cells, we conducted pairwise comparison ofSOCS1 and SOCS3 expression levels among a healthy donor group (N=55), a pre-HSCTgroup (N=17), and the recipient subgroup (N=107), which were divided according tothe occurrence of CMV viremia and acute graft-versus-host disease (aGVHD). ResultsCompared to that in the healthy donor group, SOCS1 expression was higher in the CMV+subgroup, especially in the CMV+GVHD- group, but decreased in the other subgroups. When compared to the expression in the pre-HSCT group, SOCS1 expression was significantlyhigher in the CMV+ subgroup, especially in the CMV+GVHD+ subgroup. Meanwhile, compared to that in the healthy donor group, SOCS3 expression was significantlylower in all other groups. The CMV-GVHD- subgroup showed significantly lowerSOCS3 expression compared to the CMV+ subgroup, the CMV+GVHD+ subgroup,and the CMV+GVHD- subgroup. ConclusionWe report differential expression of SOCS genes according to CMV viremia with acuteGVHD occurrence after HSCT, suggesting that regulation of SOCS expression is associatedwith CMV viremia.
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참고문헌 (30)
참고문헌 신청
Crough T / 2009 / Immunobiology of human cytomegalovirus : from bench to bedside / Clin Microbiol Rev 22:76~98
Mir MA / 2009 / Immune deficits in allogeneic hematopoietic stem cell transplant(HSCT)recipients / Mycopathologia 168:271~282
Rafailidis PI / 2008 / Severe cytomegalovirus infection in apparently immunocompetent patients : a systematic review / Virol J 5:47
Boehme KW / 2006 / Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells / J Immunol 177:7094~7102
Auletta JJ / 2012 / Emerging roles for multipotent, bone marrow-derived stromal cells in host defense / Blood 119:1801~1809
Mir MA / 2009 / Immune deficits in allogeneic hematopoietic stem cell transplant(HSCT)recipients / Mycopathologia 168:271~282
Rafailidis PI / 2008 / Severe cytomegalovirus infection in apparently immunocompetent patients : a systematic review / Virol J 5:47
Boehme KW / 2006 / Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells / J Immunol 177:7094~7102
Auletta JJ / 2012 / Emerging roles for multipotent, bone marrow-derived stromal cells in host defense / Blood 119:1801~1809
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