지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 531 - 538 (8page)
- DOI
- 10.9799/ksfan.2017.30.3.531
이용수
초록· 키워드
오류제보하기
This study was performed to investigate the effects of garlic on uncoupling protein 2 (UCP2) transcriptional regulation of UCP2- luciferase transgenic mice fed on a high fat diet to induce obesity. To examine the transcriptional regulation of UCP2, we generated transgenic mice with a UCP2 promoter (-1,830/+30 bp) containing luciferase as a reporter gene. UCP2-luciferase transgenic mice were fed a 45% high-fat diet for 8 weeks to induce obesity. Subsequently, mice were maintained on either a high-fat control diet (TG-CON), or high-fat diets supplemented with 2% (TG-GL2) or 5% (TG-GL5) garlic for a further 8 weeks. Dietary garlic reduced body weight and energy efficiency ratio in the TG-GL5 group, compared to the TG-CON group. Furthermore, garlic supplementation significantly decreased white adipose tissue fat mass and plasma levels of triglycerides, total cholesterol, and leptin in the TG-GL2 and TG-GL5 groups, compared to the TG-CON group. Specifically, UCP2 promoter activity in metabolic tissues such as liver, white adipose tissue, brown adipose tissue, and skeletal muscle was increased by garlic supplementation. These results suggest that dietary garlic was partially associated with an increase of UCP2 transcriptional activity in metabolic tissues for decreasing obesity.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Boss O / 1997 / Uncoupling protein-3 : A new member of the mitochondrial carrier family with tissue-specific expression / FEBS Lett 408:39~42
Centers for Disease Control and Prevention (CDC) / Obesity and Overweight
Chi MS / 1982 / Effects of garlic products on lipid metabolism in cholesterol-fed rats / Proc Soc Exp Biol Med 171:174~178
Choi JS / 2004 / Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats / Nutrition 20:1008~1017
Diano S / 2000 / Mitochondrial uncoupling protein 2(UCP2)in the nonhuman primate brain and pituitary / Endocinology 141:4226~4238
Centers for Disease Control and Prevention (CDC) / Obesity and Overweight
Chi MS / 1982 / Effects of garlic products on lipid metabolism in cholesterol-fed rats / Proc Soc Exp Biol Med 171:174~178
Choi JS / 2004 / Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats / Nutrition 20:1008~1017
Diano S / 2000 / Mitochondrial uncoupling protein 2(UCP2)in the nonhuman primate brain and pituitary / Endocinology 141:4226~4238
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
PI3K-Akt1 mediated Ucp1 induction in adipose tissue prevents obesity
한국식품영양과학회 학술대회발표집
2018 .10
-
Fish oil intake enhances UCP1 upregulation in adipose tissues
한국식품영양과학회 학술대회발표집
2015 .08
-
PGC-1α 형질전환 생쥐에서 마늘 분말의 체지방 감소 효과
한국식품영양학회지
2017 .10
-
A synonymous mutation of uncoupling protein 2 (UCP2) gene is associated with growth performance, carcass characteristics and meat quality in rabbits
한국축산학회지
2016 .01
-
Unripe Carica papaya Fresh Fruit Extract Protects against Methylglyoxal-Mediated Aging in Human Dermal Skin Fibroblasts
Preventive Nutrition and Food Science
2023 .09
-
Pharmacological Activation of Nrf2 by Sesamol Stimulates Ucp1 Induction in Adipocytes and Increases Energy Expenditure in Mice
한국식품영양과학회 학술대회발표집
2019 .10
-
Ginsenoside Rg1 Promotes Browning by Inducing UCP1 Expression and Mitochondrial Activity in Subcutaneous White Adipocytes
한국식품영양과학회 학술대회발표집
2018 .10
-
마늘 모형을 이용한 마늘 생산 예측
한국농림기상학회 학술발표논문집
2018 .01
-
Anti-obesity Effect of Lactic acid-Fermented Garlic Extract in High-Fat Diet Induced Obese Mice
한국식품영양과학회 학술대회발표집
2015 .08
-
Lipid Improvement Effects of Black Garlic Extract in C57BL/6J Mice Fed High-fat Diet
한국식품영양과학회 학술대회발표집
2019 .10
-
동물모델에서 인삼(Panax ginseng)의 비떨림 열발생과 미토콘드리아 기능 강화효과: 체계적 문헌고찰과 메타분석
산업식품공학
2024 .08
-
Development of semi-dried garlic of promotion of consumption of Korean garlic
한국식품영양과학회 학술대회발표집
2018 .10
-
Standardized Ecklonia Stolonifera Extract attenuates Lipid Accumulation in High-Fat Diet-Fed Mice
한국식품영양과학회 학술대회발표집
2021 .10
-
Quality Characteristics of black garlic by garlic pretreatment and enzyme treatment
한국식품영양과학회 학술대회발표집
2024 .10
-
Physicochemical and antioxidant properties of garlic (A. sativum) prepared by different heat treatment conditions
한국식품과학회지
2019 .10
-
Comparison of in vitro anti-obesity effect of raw garlic and processed garlic
한국식품영양과학회 학술대회발표집
2021 .10
-
Analysis of Quality Characteristics of Baeksan Garlic, Daeseo Garlic, and Namdo Garlic
한국식품영양과학회 학술대회발표집
2024 .10
-
Obesity and Metabolic Health: Lessons from Adipose Tissue
한국식품영양과학회 학술대회발표집
2018 .10
-
Optimization Mixing Ratio for improving antioxidant activity in the mixture of Aged-Garlic, Garlic, and Pine needle
한국식품영양과학회 학술대회발표집
2016 .10
-
Anti-Obesity Effect of Rice Bran Extract on High-Fat Diet-Induced Obese Mice
Preventive Nutrition and Food Science
2022 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0