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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 487 - 497 (11page)
- DOI
- https://doi.org/10.9799/ksfan.2021.34.5.487
이용수
초록· 키워드
오류제보하기
To investigate the industrial availability of liquid fermentation (PL-ferment) by Phellinus linteus mycelium as a postbiotics for the inhibition of inflammation, PL-ferment was fractionated into culture supernatant (CS), hot-water extract (HW) from PL-ferment, EtOH-precipitate (CP) fractionated from HW, and the dialysate (DCP) of CP. Compared to the other fractions, DCP which is expected to contain exopolysaccharide (EPS) as the major component, significantly decreased the production of NO, IL-6, and MCP-1 in LPS-induced RAW 264.7 cells, and IL-6 and IL-8 in TNF-α and IFN-γ-induced HaCaT cells. The general component analysis results showed that no significant difference in components was observed between the fractions, whereas sugar composition analysis revealed that DCP had decreased glucose and increased mannose contents compared to the other fractions. This suggests that mannose played an important role in the anti-inflammatory activity of the active fraction, DCP. Molecular weight distribution analysis revealed that DCP was mainly composed of low-molecular-weight material-removed high-molecular-weight polysaccharides of 18?638 kDa, suggesting that EPS originated from P. linteus EPS. In conclusion, our results suggest that the DCP of P. linteus mycelium fermentation using the anti-inflammatory activity could be used industrially as postbiotic material.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Baker JR / 2008 / Composition and proposed structure of a water-soluble glycan from the Keumsa Sangwhang mushroom(Phellinus linteus) / Fitoterapia 79:345~350
Blumenkrantz N / 1973 / New method for quantitative determination of uronic acids / Anal Biochem 54:484~489
Bradford MM / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72:248~254
Buchala AJ / 1987 / Structure of the β-d-glucan secreted by Phanerochaete chrysosporium in continuous culture / Carbohydr Res 165:146~149
Du B / 2017 / Characterization and anti-inflammatory potential of an exopolysaccharide from submerged mycelial culture of Schizophyllum commune / Front Pharmacol 8:252
Blumenkrantz N / 1973 / New method for quantitative determination of uronic acids / Anal Biochem 54:484~489
Bradford MM / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72:248~254
Buchala AJ / 1987 / Structure of the β-d-glucan secreted by Phanerochaete chrysosporium in continuous culture / Carbohydr Res 165:146~149
Du B / 2017 / Characterization and anti-inflammatory potential of an exopolysaccharide from submerged mycelial culture of Schizophyllum commune / Front Pharmacol 8:252
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