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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 51 - 57 (7page)
- DOI
- 10.14348/molcells.2015.2202
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초록· 키워드
오류제보하기
The Caenorhabditis elegans peroxidasins, PXN-1 and PXN- 2, are extracellular peroxidases; pxn-2 is involved in muscleepidermal attachment during embryonic morphogenesis and in specific axon guidance. Here we investigate potential roles of the other homologue of peroxidasin, pxn-1, in C.
elegans. A pxn-1 deletion mutant showed high lethality under heat-stress conditions. Using a transcriptional GFP reporter, pxn-1 expression was observed in various tissues including neurons, muscles, and hypodermis. A translational fusion showed that PXN-1::GFP was secreted and localized in extracellular matrix, particularly along body wall muscles and pharyngeal muscles. Various neuronal developmental defects were observed in pxn-1 mutants and in pxn-1 over-expressing animals, including handedness, branching, breakage, tangling, and defasciculation. These results suggest that pxn-1, like other peroxidasins, plays an important role throughout development.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Bhave, G. / 2012 / Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis / Nat. Chem. Biol 8:784~790
Brenner, S. / 1974 / The genetics of Caenorhabditis elegans / Genetics 77:71~94
Dickson, B. J. / 2002 / Molecular mechanisms of axon guidance / Science 298:1959~1964
Fidler, A. L. / 2014 / A unique covalent bond in basement membrane is a primordial innovation for tissue evolution / Proc. Natl. Acad. Sci. USA 111:331~336
Gotenstein, J. R. / 2010 / The C. elegans peroxidasin PXN-2 is essential for embryonic morphogenesis and inhibits adult axon regeneration / Development 137:3603~3613
Brenner, S. / 1974 / The genetics of Caenorhabditis elegans / Genetics 77:71~94
Dickson, B. J. / 2002 / Molecular mechanisms of axon guidance / Science 298:1959~1964
Fidler, A. L. / 2014 / A unique covalent bond in basement membrane is a primordial innovation for tissue evolution / Proc. Natl. Acad. Sci. USA 111:331~336
Gotenstein, J. R. / 2010 / The C. elegans peroxidasin PXN-2 is essential for embryonic morphogenesis and inhibits adult axon regeneration / Development 137:3603~3613
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