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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제19권 제4호
- 발행연도
- 2015.7
- 수록면
- 335 - 340 (6page)
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Here, we investigated the role of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on angiogenesis using human umbilical vein endothelial cells (HUVECs). Zerumbone inhibited HUVECs proliferation, migration and tubule formation, as well as angiogenic activity by rat aorta explants. In particular, zerumbone inhibited phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis. In vivo matrigel plug assay in mice demonstrated significant decrease in vascularization and hemoglobin content in the plugs from zerumbone-treated mice, compared with control mice. Overall, these results suggest that zerumbone inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects.
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참고문헌 (31)
참고문헌 신청
Liu RH / 2013 / Health-promoting components of fruits and vegetables in the diet / Adv Nutr 4:384S~392S
Key TJ / 2014 / Cancer in British vegetarians: updated analyses of 4998 incident cancers in a cohort of 32,491 meat eaters, 8612fish eaters, 18,298 vegetarians, and 2246 vegans / Am J Clin Nutr 100(Suppl 1):378S~385S
Bhathena SJ / 2002 / Beneficial role of dietary phytoestrogens in obesity and diabetes / Am J Clin Nutr 76:1191~1201
Canter PH / 2005 / Bringing medicinal plants into cultivation: opportunities and challenges for biotechnology / Trends Biotechnol 23:180~185
Carmeliet P / 2000 / Angiogenesis in cancer and other diseases / Nature 407:249~257
Key TJ / 2014 / Cancer in British vegetarians: updated analyses of 4998 incident cancers in a cohort of 32,491 meat eaters, 8612fish eaters, 18,298 vegetarians, and 2246 vegans / Am J Clin Nutr 100(Suppl 1):378S~385S
Bhathena SJ / 2002 / Beneficial role of dietary phytoestrogens in obesity and diabetes / Am J Clin Nutr 76:1191~1201
Canter PH / 2005 / Bringing medicinal plants into cultivation: opportunities and challenges for biotechnology / Trends Biotechnol 23:180~185
Carmeliet P / 2000 / Angiogenesis in cancer and other diseases / Nature 407:249~257
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