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논문 기본 정보

자료유형
학술저널
저자정보
Santander Lucas (Medical School, Santo Amaro University, Sao Paulo, Brazil.) Machado Nicolle Rakanidis (Laboratory of Medical Investigation LIM-56, Division of Dermatology, University of Sao Paulo, Medical School, Sao Paulo, Brazil.) Fagundes Beatriz Oliveira (Laboratory of Medical Investigation LIM-56, Division of Dermatology, University of Sao Paulo, Medical School, Sao Paulo, Brazil.) Victor Jefferson Russo (Laboratory of Medical Investigation LIM-56, Division of Dermatology, University of Sao Paulo, Medical School, Sao Paulo, Brazil.Post-Graduation Program in Health Sciences, Santo Amaro Univer)
저널정보
대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.13 No.1
발행연도
2024.1
수록면
1 - 9 (9page)
DOI
10.7774/cevr.2024.13.1.1

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초록· 키워드

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Since the 1950s decade, it has been suggested that a naturally produced or induced repertoire of immunoglobulin G (IgG) idiotypes may exert some immunoregulatory functions. In the last decades, some more advanced theories have suggested that the repertoire of IgG idiotypes may influence the development or control of some atopic diseases. In atopic dermatitis (AD), some evidence indicated that the IgG repertoire obtained from these patients could effectively mediate regulatory functions on thymic and peripheral CD4+ and CD8+ T cells. Furthermore, some recent clinical trials have corroborated the hypothesis that IgG from AD patients can ex ert regulatory functions in vivo. Here, we revised some historical aspects that yield current ap proaches developed in vitro and in vivo to elucidate a recently proposed theory termed “hooks without bait” that can strengthen the broad spectrum of research about evaluating different sets of IgG idiotypes and determine their immunological effects.

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