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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제6호
- 발행연도
- 2016.1
- 수록면
- 1,148 - 1,161 (14page)
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초록· 키워드
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Lactobacilli are universally recognized as probiotics that are widely used in the adjuvant treatment of inflammatory diseases, such as vaginitis and enteritis. With the overuse of antibiotics in recent years, the lactobacilli in the human body are killed, which could disrupt the microecological balance in the human body and affect health adversely. In this work, cephalosporin-resistant Lactobacillus casei RL20 was obtained successfully from the feces of healthy volunteers, which possessed a stable genetic set. However, the shortage of lactic acid (72.0 g/l at 48 h) by fermentation did not meet the requirement for its use in medicine. To increase the production of lactic acid, the functional genes pfk and glk were introduced into the wild strain. A yield of 144.2 g/l lactic acid was obtained in the transgenic L. casei RL20-2 after fermentation for 48 h in 1 L of basic fermentation medium with an initial glucose concentration of 100 g/l and increasing antibacterial activity. These data suggested that L. casei RL20-2 that exhibited a high yield of lactic acid may be a potential probiotic to inhibit the spread of bacterial infectious diseases and may be used for vaginitis therapy.
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참고문헌 (34)
참고문헌 신청
Amara AA / 2015 / Role of probiotics in health improvement, infection control and disease treatment and management / Saudi Pharm. J 23:107~114
Asai T / 2011 / Phylogenetic groups and cephalosporin resistance genes of Escherichia coli from diseased food-producing animals in Japan / Acta Vet. Scand 53:1~5
Blaser M / 2011 / Antibiotic overuse: stop the killing of beneficial bacteria / Nature 476:393~394
Datta R / 1993 / Proceedings of the 8 th International Trade Fair for Biotechnology: Research, Equipment, Production, Agriculture, Environment / Proceedings of the 8 th International Trade Fair for Biotechnology :221~231
Georgieva R / 2015 / Antimicrobial activity and antibiotic susceptibility of Lactobacillus and Bifidobacterium spp. intended for use as starter and probiotic cultures / Biotechnol. Biotechnol. Equip 29:84~91
Asai T / 2011 / Phylogenetic groups and cephalosporin resistance genes of Escherichia coli from diseased food-producing animals in Japan / Acta Vet. Scand 53:1~5
Blaser M / 2011 / Antibiotic overuse: stop the killing of beneficial bacteria / Nature 476:393~394
Datta R / 1993 / Proceedings of the 8 th International Trade Fair for Biotechnology: Research, Equipment, Production, Agriculture, Environment / Proceedings of the 8 th International Trade Fair for Biotechnology :221~231
Georgieva R / 2015 / Antimicrobial activity and antibiotic susceptibility of Lactobacillus and Bifidobacterium spp. intended for use as starter and probiotic cultures / Biotechnol. Biotechnol. Equip 29:84~91
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