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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 80 - 85 (6page)
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Purpose: To evaluate the effects of valproic acid (VPA), a histone deacetylase inhibitor (HDACI), on the expressionof hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in human retinalMüller cells under hypoxic conditions.
Methods: Chemical hypoxia was induced in human retinal Müller cells (MIO-M1) by treatment with increasingconcentrations of cobalt(Ⅱ) chloride (CoCl2). Müller cells were also treated with a set concentration of CoCl2,along with various concentrations of VPA. The expression of HIF-1α and VEGF in the treated Müller cells wasdetermined by enzyme-linked immunosorbent assay.
Results: Exposure of human retinal Müller cells to increasing concentrations of CoCl2 produced a dose-dependentincrease in HIF-1α expression. The addition of increasing concentrations of VPA lead to a dose-dependentdecrease in expression of HIF-1α and VEGF in Müller cells exposed to a set concentration of CoCl2.
Conclusions: HDACI VPA downregulated the expressions of HIF-1α and VEGF in human retinal Müller cellsunder hypoxic conditions. Using HDACI to target HIF-1α expression in Müller cells could be a new therapeuticstrategy for the treatment of retinal vascular diseases.
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참고문헌 (26)
참고문헌 신청
Adamis AP / 1994 / Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy / Am J Ophthalmol 118 : 445 ~ 450
Aiello LP / 1994 / Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders / N Engl J Med 331 : 1480 ~ 1487
Aiello LP / 1995 / Hypoxic regulation of vascular endothelial growth factor in retinal cells / Arch Ophthalmol 113 : 1538 ~ 1544
Bai Y / 2009 / Muller cell-derived VEGF is a significant contributor to retinal neovascularization / J Pathol 219 : 446 ~ 454
Brown JM / 2004 / Exploiting tumour hypoxia in cancer treatment / Nat Rev Cancer 4 : 437 ~ 447
Aiello LP / 1994 / Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders / N Engl J Med 331 : 1480 ~ 1487
Aiello LP / 1995 / Hypoxic regulation of vascular endothelial growth factor in retinal cells / Arch Ophthalmol 113 : 1538 ~ 1544
Bai Y / 2009 / Muller cell-derived VEGF is a significant contributor to retinal neovascularization / J Pathol 219 : 446 ~ 454
Brown JM / 2004 / Exploiting tumour hypoxia in cancer treatment / Nat Rev Cancer 4 : 437 ~ 447
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