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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제1호
- 발행연도
- 2016.1
- 수록면
- 53 - 62 (10page)
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초록· 키워드
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Mesenchymal stem cells (MSCs) in the bone marrow and other somatic tissues reside in an environment with relative low oxygen tension. Cobalt chloride (CoCl2) can mimic hypoxic conditions through transcriptional changes of some genes including hypoxia-inducible factor-1a (HIF-1a) and vascular endothelial growth factor (VEGF). This study evaluated the potential role of CoCl2 preconditioning on multi-lineage differentiation of C3H/10T1/2, a murine MSC line to understand its possible molecular mechanisms in vitro. CoCl2 treatment of MSCs markedly increased HIF-1a and VEGF mRNA, and protein expression of HIF-1a. Temporary preconditioning of MSCs with CoCl2 induced up-regulation of osteogenic markers including alkaline phosphatase, osteocalcin, and type I collagen during osteogenic differentiation, followed by enhanced mineralization. CoCl2 also increased chondrogenic markers including aggrecan, sox9, and type II collagen, and promoted chondrocyte differentiation. CoCl2 suppressed the expression of adipogenic markers including PPARγ, aP2, and C/EBPa, and inhibited adipogenesis. Temporary preconditioning with CoCl2 could affect the multi-lineage differentiation of MSCs.
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참고문헌 (41)
참고문헌 신청
Baksh D / 2004 / Adult mesenchymal stem cells : characterization, differentiation, and application in cell and gene therapy / J Cell Mol Med 8:301~316
Tsai CC / 2011 / Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIFTWIST / Blood 117:459~469
Bruder SP / 1994 / Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy / J Cell Biochem 56:283~294
Cicione C / 2013 / Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential / Stem Cells Int 2013:232896
Ren H / 2006 / Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions / Biochem Biophys Res Commun 347:12~21
Tsai CC / 2011 / Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIFTWIST / Blood 117:459~469
Bruder SP / 1994 / Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy / J Cell Biochem 56:283~294
Cicione C / 2013 / Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential / Stem Cells Int 2013:232896
Ren H / 2006 / Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions / Biochem Biophys Res Commun 347:12~21
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