지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Calcitonin gene-related peptide (CGRP) is the most abundant neuropeptide in primary afferent sensory neurons. Exogenous CGRP can induce cell death in kidney tubular cells. The objective of this study was to determine whether exogenous CGRP could induce reactive oxygen species (ROS) production in kidney proximal tubule epithelial cells and whether CGRP-induced ROS production might contribute to cell death. In HK-2, LLCPK1 and TCMK-1 cell lines derived from human, pig, and mouse respectively, administration of CGRP increased cell death in time- and dose-dependent manners, as demonstrated by decreased cell viability. Exogenous CGRP also increased ROS production levels in those cell lines. Treatment with CGRP receptor antagonist (CGRP<SUP>8-37</SUP>) significantly inhibited the increases in cell death and ROS production in CGRP-exposed cells. Furthermore, treatment with a ROS scavenger (MnTMPyP) markedly reduced kidney proximal tubule epithelial cell death after CGRP administration. Taken together, these data suggest that extraneural CGRP can induce cell death through excessive oxidative stress in kidney proximal tubule epithelial cells.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
Russell FA / 2014 / Calcitonin gene-related peptide: physiology and pathophysiology / Physiol Rev 94:1099~1142
Ferguson M / 1988 / Ultrastructural localization and characterization of sensory nerves in the rat kidney / J Comp Neurol 274:9~16
Watkins HA / 2013 / Structure-activity relationships for alpha-calcitonin gene-related peptide / Br J Pharmacol 170:1308~1322
Calò LA / 2012 / Calcitonin gene-related peptide, heme oxygenase-1, endothelial progenitor cells and nitric oxide-dependent vasodilation relationships in a human model of angiotensin II type- 1 receptor antagonism / J Hypertens 30:1406~1413
Kim J / 2013 / Renal nerves drive interstitial fibrogenesis in obstructive nephropathy / J Am Soc Nephrol 24:229~242
Ferguson M / 1988 / Ultrastructural localization and characterization of sensory nerves in the rat kidney / J Comp Neurol 274:9~16
Watkins HA / 2013 / Structure-activity relationships for alpha-calcitonin gene-related peptide / Br J Pharmacol 170:1308~1322
Calò LA / 2012 / Calcitonin gene-related peptide, heme oxygenase-1, endothelial progenitor cells and nitric oxide-dependent vasodilation relationships in a human model of angiotensin II type- 1 receptor antagonism / J Hypertens 30:1406~1413
Kim J / 2013 / Renal nerves drive interstitial fibrogenesis in obstructive nephropathy / J Am Soc Nephrol 24:229~242
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Extraneural CGRP Upregulates TGF-β1 through RAMP1 Signaling during Mechanical Stretch in Kidney Proximal Tubule Epithelial Cells
해부·생물인류학
2020 .12
-
Aging changes in renal proximal tubule
대한체질인류학회 학술대회 연제 초록
2021 .05
-
Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies
Kidney Research and Clinical Practice
2021 .01
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Nanoscale imaging of rat atrial myocytes by scanning ion conductance microscopy reveals heterogeneity of T-tubule openings and ultrastructure of the cell membrane
The Korean Journal of Physiology & Pharmacology
2020 .01
-
T helper 17 cells in the pathophysiology of acute and chronic kidney disease
Kidney Research and Clinical Practice
2021 .01
-
The protective effect of Sargassum horneri extract on oxidative stress induced by particulate matter in MLE-12 cells
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Cell Death and Liver Disease
Gut and Liver
2020 .01
-
The Role of Reactive Oxygen Species in Regulating T Cell-mediated Immunity and Disease
Immune Network
2018 .02
-
Physiological understanding of host-microbial pathogen interactions in the gut
Korean Journal of Veterinary Research(대한수의학회지)
2016 .07
-
Vimentin Targeted Nano-gene Carrier for Treatment of Renal Diseases
Journal of Korean Medical Science
2021 .12
-
Structural modifications of the prostate in hypoxia, oxidative stress, and chronic ischemia
Investigative and Clinical Urology
2015 .01
-
The Preventive Effect of 5-Iodo-6-Amino-1,2-Benzopyrone on Apoptosis of Rat Heart-derived Cells induced by Oxidative Stress
대한의생명과학회지
2022 .12
-
SARS-CoV-2 Infection of Airway Epithelial Cells
Immune Network
2021 .02
-
Pathomechanism of oxidative stress in cardiovascularrenal remodeling and therapeutic strategies
Kidney Research and Clinical Practice
2022 .09
-
Cell cycle arrest of alveolar epithelial cells is critical in the pathogenesis of idiopathic pulmonary fibrosis
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Expression and Role of Calcitonin Gene-Related Peptide in Patients With Chronic Rhinosinusitis With Nasal Polyposis
대한이비인후-두경부외과학회지
2022 .04
-
Assessing the Impact of Commonly Used Industrial Preservatives on Oxidative Stress and Cell Viability in Human Bronchial Epithelial Cells (BEAS-2B)
환경독성보건학회 심포지엄 및 학술대회
2023 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2020-511-000232055