Risk Factors Related to Poor Threshold, Discrimination, and Identification Scores in Patients with Chronic Rhinosinusitis with Olfactory Dysfunction

강대웅; 민혜규; 권오은; 김성완; 민진영

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자료유형: 학술저널

저자정보: 강대웅 (경희대학교) 민혜규 (경희대학교 이비인후과) 권오은 (경희대학교) 김성완 (경희대학교) 민진영 (경희대학교)

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후-두경부외과학회지 제63권 제8호

발행연도: 2020.1

수록면: 358 - 368 (11page)

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Background and Objectives Although patients with chronic rhinosinusitis (CRS) presenta similar degree of olfactory dysfunction, their impairments in threshold, discrimination, andidentification test results may vary. We investigated factors related to each of these componentsusing the Korean version of the Sniffin’ Sticks test II in CRS patients. Subjects and Method A total of 120 CRS patients with olfactory dysfunction were enrolledand assigned to hyposmia and anosmia groups. Correlation between the three components wereexamined in both groups. We also subdivided patients into higher- and lower-score groups accordingto the threshold, discrimination, and identification scores within the hyposmia andanosmia groups to determine associated factors among the demographic factors, CRS severityon computed tomography (CT) and endoscopic findings. Results Threshold, discrimination, and identification scores were significantly correlated inhyposmia patients. Age [odds ratio (OR), 0.94] was associated with the threshold score, and theanterior olfactory cleft opacification score (OR, 1.31) on CT was associated with identificationdifficulties in hyposmia patients. The posterior olfactory cleft opacification score was associatedwith threshold (OR, 2.76) and identification difficulties (OR, 1.68) in anosmia patients. However,we could not identify significant risk factors for discrimination in both groups. Conclusion We demonstrated that the three components of the olfactory function test forCRS are significantly correlated in patients with hyposmia. Age was associated with thresholdscore in hyposmia patients and CRS severity, and with discrimination scores in both hyposmiaand anosmia patients. These findings will help the understanding of pathophysiology of CRSrelatedolfactory dysfunction.

#Endoscopy #Nasal mucosa #Olfaction disorder #Olfactory nerve injuries

참고문헌 (28)

참고문헌 신청

Kajiya K / 2001 / Molecular bases of odor discrimination: Reconstitution of olfactory receptors that recognize overlapping sets of odorants / J Neurosci 21(16):6018~6025

Zusho H / 1982 / Posttraumatic anosmia / Arch Otolaryngol 108(2):90~92

Litvack JR / 2009 / Olfactory function and disease severity in chronic rhinosinusitis / Am J Rhinol Allergy 23(2):139~144

Croy I / 2014 / Olfactory disorders and quality of life--an updated review / Chem Senses 39(3):185~194

Raviv JR / 2004 / Chronic sinusitis and olfactory dysfunction / Otolaryngol Clin North Am 37(6):1143~1157

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