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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.11 No.1
- 발행연도
- 2021.1
- 수록면
- 39 - 53 (15page)
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초록· 키워드
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cells (MSCs) are known to have a strong ability for homing. MSCs labeled with superparamagnetic iron oxide nanoparticles(SPIONs) exhibit enhanced homing due to magnetic attraction. We have designed a SPION that has a cluster core ofiron oxide-based nanoparticles coated with PLGA-Cy5.5. We optimized the nanoparticles for internalization to enable thetransport of PCS nanoparticles through endocytosis into MSCs. The migration of magnetized MSCs with SPION by staticmagnets was seen in vitro. The auditory hair cells do not regenerate once damaged, ototoxic mouse model was generated byadministration of kanamycin and furosemide. SPION labeled MSC’s were administered through different injection routes inthe ototoxic animal model. As result, the intratympanic administration group with magnet had the highest number of cells inthe brain followed by the liver, cochlea, and kidney as compared to those in the control groups. The synthesized PCS (polyclustered superparamagnetic iron oxide) nanoparticles, together with MSCs, by magnetic attraction, could synergisticallyenhance stem cell delivery.
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참고문헌 (30)
참고문헌 신청
Oliva J / 2019 / Therapeutic properties of mesenchymal stem cell on organ ischemia-reperfusion injury / Int J Mol Sci 20:5511
Yun WS / 2018 / Enhanced homing technique of mesenchymal stem cells using iron oxide nanoparticles by magnetic attraction in olfactory-injured mouse models / Int J Mol Sci 19:1376
Pittenger MF / 1999 / Multilineage potential of adult human mesenchymal stem cells / Science 284:143~147
Devine SM / 2003 / Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates / Blood 101:2999~3001
Jeffrey M. Karp / 2009 / Mesenchymal Stem Cell Homing: The Devil Is in the Details / Cell Stem Cell 4(3):P206~P216
Yun WS / 2018 / Enhanced homing technique of mesenchymal stem cells using iron oxide nanoparticles by magnetic attraction in olfactory-injured mouse models / Int J Mol Sci 19:1376
Pittenger MF / 1999 / Multilineage potential of adult human mesenchymal stem cells / Science 284:143~147
Devine SM / 2003 / Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates / Blood 101:2999~3001
Jeffrey M. Karp / 2009 / Mesenchymal Stem Cell Homing: The Devil Is in the Details / Cell Stem Cell 4(3):P206~P216
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