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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 416 - 422 (7page)
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초록· 키워드
오류제보하기
Background: The selection of anesthetic agents is important in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome patient because serious and unexpected complications can occur after anesthetic exposure. Case: A 30-year-old man with MELAS syndrome and sepsis underwent colectomy. Propofol was administered by step-wise until target effect-site concentration (Ce) 1.0 μg/ml and stopped for the loss of consciousness and to avoid hemodynamic instability. After the loss of consciousness, total intravenous anesthesia (TIVA) using dexmedetomidine (1.0 μg/ml/h) and remifentanil (1–4 ng/ml of Ce) was performed for the maintenance of anesthesia to avoid malignant hyperthermia and mitochondrial dysfunction. During the surgery, the bispectral index score stayed between 26 and 44, and increased to 97 after the end of anesthesia. Conclusions: TIVA with dexmedetomidine and remifentanil as non-triggering anesthetic agents in patients with MELAS syndrome and systemic sepsis may have advantages to decrease damages associated with mitochondrial stress and metabolic burden.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
박진석 / 2010 / Total intravenous anesthesia with propofol and remifentanil in a patient with MELAS syndrome -A case report- / Korean Journal of Anesthesiology 58(4):409~412
Niezgoda J / 2013 / Anesthetic considerations in patients with mitochondrial defects / Paediatr Anaesth 23:785~793
Lee S / 2012 / Pharmacokinetics and pharmacodynamics of intravenous dexmedetomidine in healthy Korean subjects / J Clin Pharm Ther 37:698~703
Fujita Y / 2013 / A comparison between dosages and plasma concentrations of dexmedetomidine in clinically ill patients : a prospective, observational, cohort study in Japan / J Intensive Care 1:15
Sproule DM / 2008 / Mitochondrial encephalopathy, lactic acidosis, and strokelike episodes : basic concepts, clinical phenotype, and therapeutic management of MELAS syndrome / Ann N Y Acad Sci 1142:133~158
Niezgoda J / 2013 / Anesthetic considerations in patients with mitochondrial defects / Paediatr Anaesth 23:785~793
Lee S / 2012 / Pharmacokinetics and pharmacodynamics of intravenous dexmedetomidine in healthy Korean subjects / J Clin Pharm Ther 37:698~703
Fujita Y / 2013 / A comparison between dosages and plasma concentrations of dexmedetomidine in clinically ill patients : a prospective, observational, cohort study in Japan / J Intensive Care 1:15
Sproule DM / 2008 / Mitochondrial encephalopathy, lactic acidosis, and strokelike episodes : basic concepts, clinical phenotype, and therapeutic management of MELAS syndrome / Ann N Y Acad Sci 1142:133~158
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