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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 439 - 445 (7page)
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초록· 키워드
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Background: Previous studies have reported that glypican-4 (GPC4) regulates insulin signaling by interacting with insulin receptorand through adipocyte differentiation. However, GPC4 has not been studied with regard to its effects on clinical factors in patientswith type 2 diabetes mellitus (T2DM). We aimed to identify factors associated with GPC4 level in T2DM. Methods: Between January 2010 and December 2013, we selected 152 subjects with T2DM and collected serum and plasma intotubes pretreated with aprotinin and dipeptidyl peptidase-4 inhibitor to preserve active gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1). GPC4, active GLP-1, active GIP, and other factors were measured in these plasma samples. We performeda linear regression analysis to identify factors associated with GPC4 level. Results: The subjects had a mean age of 58.1 years, were mildly obese (mean body mass index [BMI], 26.1 kg/m2), had T2DM oflong-duration (mean, 101.3 months), glycated hemoglobin 7.5%, low insulin secretion, and low insulin resistance (mean homeostaticmodel assessment of insulin resistance [HOMA-IR], 1.2). Their mean GPC4 was 2.0±0.2 ng/mL. In multivariate analysis, GPC4was independently associated with age (β=0.224, P=0.009), and levels of active GLP-1 (β=0.171, P=0.049) and aspartate aminotransferase(AST; β=–0.176, P=0.043) after being adjusted for other clinical factors. Conclusion: GPC4 was independently associated with age, active GLP-1, and AST in T2DM patients, but was not associated withHOMA-IR and BMI, which are well known factors related to GPC4. Further study is needed to identify the mechanisms of the associationbetween GPC4 and basal active GLP-1 levels.
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참고문헌 (16)
참고문헌 신청
Lillioja S / 1993 / Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians / N Engl J Med 329:1988~1992
Chen KW / 1995 / Earlier appearance of impaired insulin secretion than of visceral adiposity in the pathogenesis of NIDDM. 5-Year follow-up of initially nondiabetic Japanese-American men / Diabetes Care 18:747~753
Hurt RT / 2010 / The obesity epidemic: challenges, health initiatives, and implications for gastroenterologists / Gastroenterol Hepatol (N Y) 6:780~792
Fico A / 2011 / Fine-tuning of cell signaling by glypicans / Cell Mol Life Sci 68:923~929
Gesta S / 2006 / Evidence for a role of developmental genes in the origin of obesity and body fat distribution / Proc Natl Acad Sci U S A 103:6676~6681
Chen KW / 1995 / Earlier appearance of impaired insulin secretion than of visceral adiposity in the pathogenesis of NIDDM. 5-Year follow-up of initially nondiabetic Japanese-American men / Diabetes Care 18:747~753
Hurt RT / 2010 / The obesity epidemic: challenges, health initiatives, and implications for gastroenterologists / Gastroenterol Hepatol (N Y) 6:780~792
Fico A / 2011 / Fine-tuning of cell signaling by glypicans / Cell Mol Life Sci 68:923~929
Gesta S / 2006 / Evidence for a role of developmental genes in the origin of obesity and body fat distribution / Proc Natl Acad Sci U S A 103:6676~6681
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