The effects of loading dose administration rate of dexmedetomidine on sedation and dexmedetomidine requirement in elderly patients undergoing spinal anesthesia

Hsi Chiang Kung; Chia Chi Cheng; 강동희; 정형주; 신혜영; 김두식; 류시정; 김경한; 김주덕

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자료유형: 학술저널

저자정보: Hsi Chiang Kung (고신대학교) Chia Chi Cheng (고신대학교) 강동희 (고신대학교) 정형주 (고신대학교) 신혜영 (고신대학교) 김두식 (고신대학교) 류시정 (고신대학교) 김경한 (고신대학교) 김주덕 (고신대학교)

저널정보: 대한마취통증의학회(구 대한마취과학회) Anesthesia and Pain Medicine Anesthesia and Pain Medicine Vol.13 No.3

발행연도: 2018.1

수록면: 264 - 270 (7page)

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Background: This study evaluated the effect of decrease in loading dose administration rate of dexmedetomidine (DMT) on sedation and DMT requirement in elderly patients. Methods: Fifty-eight patients over 65 years old with ASA I–II who were planned to receive DMT sedation during spinal anesthesia were randomly assigned to two groups. Group S (n = 29) received a 0.5 μg/kg DMT loading dose over 20 minutes, while group C (n = 29) received the DMT loading dose over 10 minutes. Then, both groups received a continuous infusion of 0.4 μg/kg/h. The sedative status was recorded before and at 5, 10, 15, 20, 25, and 30 minutes after administration of DMT and at the end of the anesthesia according to the Ramsay sedation scale (RSS). Also, the time to reach RSS- 3 (patients asleep, responsive to commands) and the dose of DMT until reaching RSS-3 were recorded. Results: The time to reach RSS-3 was similar between the two groups (group S = 16.0 ± 4.3 minutes vs. group C = 15.5 ± 4.2 minutes, P = 0.673). However, the DMT required to reach RSS-3 in group S was significantly lower than that in group C (23.3 ± 7.1 vs. 32.5 ± 6.0 μg, P < 0.001). There was no difference in RSS between the two groups from the administration of DMT to the end of the anesthesia (P = 0.927). Conclusions: Decreasing the administration rate of the DMT loading dose did not delay the onset of RSS-3 sedation and reduced the DMT requirement in elderly patients.

참고문헌 (23)

참고문헌 신청

Hall JE / 2000 / Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions / Anesth Analg 90:699~705

Gertler R / 2001 / Dexmedetomidine: a novel sedative-analgesic agent / Proc (Bayl Univ Med Cent) 14:13~21

Gurbet A / 2006 / Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements / Can J Anaesth 53:646~652

Carollo DS / 2008 / Dexmedetomidine: a review of clinical applications / Curr Opin Anaesthesiol 21:457~461

Fan TW / 2013 / Comparison of dexmedetomidine and midazolam for conscious sedation in dental surgery monitored by bispectral index / Br J Oral Maxillofac Surg 51:428~433

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Hsi Chiang Kung

소속기관 고신대학교

주요연구분야 의약학 > 임상의학 > 마취과학

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Chia Chi Cheng

소속기관 고신대학교

주요연구분야 의약학 > 임상의학 > 마취과학

논문수 1 이용수 0

강동희

소속기관 고신대학교