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자료유형
학술저널
저자정보
김현아 (동아대학교) 조재구 (동아대학교) 김묘징 (동아대학교)
저널정보
대한주산의학회 Perinatology Perinatology Vol.27 No.3
발행연도
2016.1
수록면
168 - 173 (6page)

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Purpose: Few studies have investigated the neurological complications of rotavirus infection in newborns. This study reports on clinical characteristics of newborns with seizures during rotavirus infection period and the neurological complications through case reports of infants who experienced seizures during rotavirus infection and demonstrated deep white matter injury on brain magnetic resonance imaging (MRI). Methods: The study retrospectively investigated the medical records of newborn patients with positive rotavirus results who admitted to the neonatal intensive care unit of Dong-a University Hospital between January 2010 and May 2015. We analyzed the clinical characteristics of patients with seizures compared to without seizures among the patients of positive rotavirus results. The clinical characteristics of seizure patients according to the stool rotavirus antigen test results (positive vs. negative) and MRI results (normal vs. abnormal) were compared and analyzed. Results: Of the 144 infants with positive rotavirus results, 17 infants (11.8%) had the seizures. These 17 patients showed no other symptom except seizures, positive rotavirus results predo- minantly at 4-6 days after birth, and more abnormal MRI results compared to without seizures. These results investigated in the seizure infants with positive rotavirus and infants of abnormal MRI results with positive rotavirus in same trend. In 15 newborns who showed positive stool test results and abnormal MRI results, seizure symptoms occurred at 4-6 days after birth, mostly following a pattern of clonic seizures. On MRI, all these newborns showed cerebral deep white matter injury in areas including the corpus callosum (CC) and internal capsule. Six out of 15 newborns underwent follow-up MRI scans, and five of them showed porencephalic white matter disease or periventricular leukomalacia. Conclusion: In cases when a newborn shows seizures and cerebral deep white matter injury on diffusion-weighted MRI, rotavirus infection should be strongly suspected, and the patient should be subjected to long-term follow-up for neurological development.

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