지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.11
- 수록면
- 809 - 818 (10page)
이용수
이 논문의 연구 히스토리 (6)
2022
The non-saponin fraction of Korean Red Ginseng ameliorates sarcopenia by regulating immune homeostasis in 22e26-month-old C57BL/6J mice
Hyun-Ji Oh
,
Heegu Jin
,
Boo-Yong Lee
Journal of Ginseng Research
2022.11
학술저널
Silk Peptide Improves Sarcopenia in 22-26-month-old C57BL/6 mice
Hyun-Ji Oh
,
Heegu Jin
,
Hyein Han
외 1명
한국식품영양과학회 학술대회발표집
2022.10
학술대회자료
2021
Gintonin-enriched fraction improves sarcopenia by maintaining immune homeostasis in 20- to 24-month-old C57BL/6J mice
Hyun-Ji Oh
,
Heegu Jin
,
Seung-Yeol Nah
외 1명
Journal of Ginseng Research
2021.11
학술저널
Non-Saponin Fraction of Korean Red Ginseng Regulates Immunosenescence in 20- to 24-Month-Old C57BL/6J Mice
Hyun-Ji Oh
,
Heegu Jin
,
Hyeonji Woo
외 2명
한국식품영양과학회 학술대회발표집
2021.10
학술대회자료
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Background: The non-saponin fraction (NSF) of Korean Red Ginseng is a powder in which saponin is eliminated from red ginseng concentrate by fractionation. In this study, we examined the effect of NSF on age-associated sarcopenia in old mice.
Methods: NSF (50 or 200 mg/kg/day) was administered orally daily to young (3e6-month-old) and old (20e24-month-old) C57BL/6 J mice for 6 weeks. Body weight and grip strength were assessed once a week during the oral administration period. The gastrocnemius and quadriceps muscle were excised, and the muscle fiber size was compared through hematoxylin and eosin staining. In addition, the effect of NSF on sarcopenia and inflammation/oxidative stress-related factors in hindlimb muscles was investigated by western blotting. Flow cytometry analysis was conducted to investigate the effect of NSF on immune homeostasis. Blood samples were collected by cardiac puncture, and the serum levels of insulin-like growth factor 1, pro-inflammatory cytokines, and glutathione were evaluated.
Results: NSF significantly alleviated muscle strength, mass, and also fiber size in old mice. Age-associated impairment of immune homeostasis was recovered by NSF through retaining CD11b<SUP>+</SUP>F4/80<SUP>+</SUP> macrophages and regulating inflammatory biomarkers. NSF also decreased the age-induced expression of oxidative stress factors. Taken together, NSF showed the effect of improving sarcopenia by inhibiting lowgrade chronic inflammatory/oxidative stress factors.
Conclusion: NSF exhibited anti-sarcopenia effects by regulating chronic inflammation and oxidative stress in old mice. Thus, we suggest that NSF is a promising restorative agent that can be used to improve sarcopenia in the elderly as well as maintain immune homeostasis.
Methods: NSF (50 or 200 mg/kg/day) was administered orally daily to young (3e6-month-old) and old (20e24-month-old) C57BL/6 J mice for 6 weeks. Body weight and grip strength were assessed once a week during the oral administration period. The gastrocnemius and quadriceps muscle were excised, and the muscle fiber size was compared through hematoxylin and eosin staining. In addition, the effect of NSF on sarcopenia and inflammation/oxidative stress-related factors in hindlimb muscles was investigated by western blotting. Flow cytometry analysis was conducted to investigate the effect of NSF on immune homeostasis. Blood samples were collected by cardiac puncture, and the serum levels of insulin-like growth factor 1, pro-inflammatory cytokines, and glutathione were evaluated.
Results: NSF significantly alleviated muscle strength, mass, and also fiber size in old mice. Age-associated impairment of immune homeostasis was recovered by NSF through retaining CD11b<SUP>+</SUP>F4/80<SUP>+</SUP> macrophages and regulating inflammatory biomarkers. NSF also decreased the age-induced expression of oxidative stress factors. Taken together, NSF showed the effect of improving sarcopenia by inhibiting lowgrade chronic inflammatory/oxidative stress factors.
Conclusion: NSF exhibited anti-sarcopenia effects by regulating chronic inflammation and oxidative stress in old mice. Thus, we suggest that NSF is a promising restorative agent that can be used to improve sarcopenia in the elderly as well as maintain immune homeostasis.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Ethics statement
4. Results
5. Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Gastroprotective effects of the nonsaponin fraction of Korean Red Ginseng through cyclooxygenase-1 upregulation
Journal of Ginseng Research
2020 .07
-
통합적 평가 도구를 활용한 근감소증 분석 : 국내 65세 이상 노인을 대상으로
대한통합의학회지
2023 .02
-
Comparison of anticancer activities of Korean Red Ginseng-derived fractions
Journal of Ginseng Research
2017 .07
-
Inhibitory effects of total saponin from Korean Red Ginseng on [Ca2+]i mobilization through phosphorylation of cyclic adenosine monophosphate-dependent protein kinase catalytic subunit and inositol 1,4,5-trisphosphate receptor type I in human platelets
Journal of Ginseng Research
2015 .10
-
Gintonin-enriched fraction improves sarcopenia by maintaining immune homeostasis in 20- to 24-month-old C57BL/6J mice
Journal of Ginseng Research
2021 .11
-
Influence of sarcopenia focused on critically ill patients
Acute and Critical Care
2021 .01
-
Recent Update on the Prevalence of Sarcopenia in Koreans: Findings from the Korea National Health and Nutrition Examination Survey
대한골대사학회지
2024 .05
-
Association of Dietary Variety Status and Sarcopenia in Korean Elderly
대한골대사학회지
2020 .01
-
Recent Update on Sarcopenia
대한외과학회 학술대회 초록집
2023 .05
-
Two Types of Mouse Models for Sarcopenia Research: Senescence Acceleration and Genetic Modification Models
대한골대사학회지
2021 .08
-
Sarcopenia Related to Various Type of Surgery
대한외과학회 학술대회 초록집
2020 .11
-
Rodent Model of Muscular Atrophy for Sarcopenia Study
대한골대사학회지
2020 .01
-
Molecular mechanisms and therapeutic interventions in sarcopenia
Osteoporosis and Sarcopenia
2017 .01
-
Diabetic Peripheral Neuropathy as a Risk Factor for Sarcopenia
Annals of geriatric medicine and research
2019 .01
-
Korean Working Group on Sarcopenia Guideline: Expert Consensus on Sarcopenia Screening and Diagnosis by the Korean Society of Sarcopenia, the Korean Society for Bone and Mineral Research, and the Korean Geriatrics Society
Annals of geriatric medicine and research
2023 .03
-
Sarcopenia in Korea: Prevalence and Clinical Aspects
Annals of geriatric medicine and research
2015 .01
-
Physiological and pharmacological features of the non-saponin components in Korean Red Ginseng
Journal of Ginseng Research
2020 .07
-
Non-saponin fractions of Korean Red Ginseng inhibit AIM2 inflammasome activation
한국실험동물학회 학술발표대회 논문집
2020 .07
-
홍삼의 Dexamethasone 유도 근감소증 모델 백서에 대한 효과 연구
대한한방내과학회지
2018 .01
-
Implications of red Panax ginseng in oxidative stress associated chronic diseases
Journal of Ginseng Research
2017 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-524-000241728