지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.9
- 수록면
- 121 - 129 (9page)
- DOI
- 10.20307/nps.2022.28.3.121
이용수
초록· 키워드
오류제보하기
Despite considerable efforts, cancer remains an aggressive killer worldwide. Chemotherapeutic drugs that are currently in use lead to destructive side effects and have not succeeded in fulfilling expectations. For centuries, medicinal plants are used for treating various diseases and are also known to have anticancer activity. The main aim of this research was to evaluate antiproliferative activity of saffron, clove, fenugreek, and green tea on Vero and MDA-MB-231 cell lines and to subsequently analyze the effect of these extracts on IRAK-4, TAK1, IKK-alpha, IKK-beta, NF-Kappa B, IRF3, IRF7 genes in Toll Like Receptors (TLRs) pathway. Antiproliferative assay was done by Neutral Red Dye uptake assay. Methanolic extract of green tea was found to be most effective against both cell lines as IC<SUB>50</SUB> was achieved at least concentration of the extract. For molecular studies, MDA-MB-231 cells were sensitized with methanolic extract of green tea at same IC<SUB>50</SUB>, and RT-PCR was performed to determine the relative expression of genes. Expression of IRAK-4, TAK1, IKK-beta, NF-Kappa B, IRF3 genes was down regulated and IRF7 and IKKalpha was upregulated. Green tea has a potential cytotoxic effect on both cell lines which was demonstrated by its effect on the expression of (TLRs) pathway genes.
목차
Abstract
Introduction
Experimental
Results and Discussion
References
참고문헌 (23)
참고문헌 신청
Baskar, R.; Lee, K. A.; Yeo, R.; Yeoh, K. W. Int. J. Med. Sci. 2012, 9, 193-199.
Housman, G.; Byler, S.; Heerboth, S.; Lapinska, K.; Longacre, M.; Snyder, N.; Sarkar, S. Cancers 2014, 6, 1769-1792.
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Zajączkowska, R.; Kocot-Kępska, M.; Leppert, W.; Wrzosek, A.; Mika, J.; Wordliczek, J. Int. J. Mol. Sci. 2019, 20, 1451.
Grisold, W.; Cavaletti, G.; Windebank, A. J. Neuro. Oncol. 2012, 14, iv45-iv54.
Housman, G.; Byler, S.; Heerboth, S.; Lapinska, K.; Longacre, M.; Snyder, N.; Sarkar, S. Cancers 2014, 6, 1769-1792.
Weber, G. F. Mol. Ther. Cancer 2014, 2014, 9-112.
Zajączkowska, R.; Kocot-Kępska, M.; Leppert, W.; Wrzosek, A.; Mika, J.; Wordliczek, J. Int. J. Mol. Sci. 2019, 20, 1451.
Grisold, W.; Cavaletti, G.; Windebank, A. J. Neuro. Oncol. 2012, 14, iv45-iv54.
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