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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 486 - 489 (4page)
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Human melanocytes are not simply pigment-producing cells. It may be part of the inflammatory response, during which the pigmentary system may produce more melanin or suppress melanization. Toll-like receptors (TLRs) have been implicated in both innate host defense against pathogens and inflammatory response. Therefore, it may be possible that activation of TLRs in melanocytes may play a role in the modulation of melanogenesis. In this study, we investigated whether normal human melanocytes expressed TLRs and analyzed pigmentation changes upon TLR stimulation. The expression of TLR1∼10 mRNA in cultured human melanocyte was analyzed using RT-PCR, Western blotting and immunocytochemistry. Human melanocytes constitutively express mRNA and protein for TLR2, 3, 4, 5, 7, 9 and 10.
Stimulation of TLR1/2 and 4 with Pam3CSK4 and lipopolysaccharide induced pigmentation of melanocytes. Activation of TLR5 and 7 with flagellin and imiquimod treatments reduced pigmentation of melanocytes and zebrafish. In summary, the results provided evidence for TLRs expression in normal human melanocytes. It is speculated that a response of melanocyte to TLR ligands may play a role in the pigmentary change in the skin. (Ann Dermatol 22(4) 486∼489, 2010)
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등록된 정보가 없습니다.
참고문헌 (7)
참고문헌 신청
Ahn JH / 2008 / Human melanocytes express functional Toll-like receptor 4 / Exp Dermatol 17 : 412 ~ 417
Choi TY / 2007 / Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds / Pigment Cell Res 20 : 120 ~ 127
Kang HY / 2009 / Imiquimod,a Toll-like receptor 7 agonist,inhibits melanogenesis and proliferation of human melanocytes / J Invest Dermatol 129 : 243 ~ 246
Mackintosh JA / 2001 / The antimicrobial properties of melanocytes,melanosomes and melanin and the evolution of black skin / J Theor Biol 211 : 101 ~ 113
Plonka PM / 2009 / What are melanocytes really doing all day long...? / Exp Dermatol 18 : 799 ~ 819
Choi TY / 2007 / Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds / Pigment Cell Res 20 : 120 ~ 127
Kang HY / 2009 / Imiquimod,a Toll-like receptor 7 agonist,inhibits melanogenesis and proliferation of human melanocytes / J Invest Dermatol 129 : 243 ~ 246
Mackintosh JA / 2001 / The antimicrobial properties of melanocytes,melanosomes and melanin and the evolution of black skin / J Theor Biol 211 : 101 ~ 113
Plonka PM / 2009 / What are melanocytes really doing all day long...? / Exp Dermatol 18 : 799 ~ 819
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