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논문 기본 정보

자료유형
학술저널
저자정보
Seock-Yeon Hwang (대전대학교) Sang-Hyun Sohn (건국대학교) Jae-Joon Wee (한국인삼공사) Jin-Bae Yang (대전대학교) Jong-Soo Kyung (한국인삼공사) Yi-Seong Kwak (한국인삼공사) Sung-Won Kim (건국대학교) Si-Kwan Kim (건국대학교)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.34 No.4
발행연도
2010.12
수록면
327 - 335 (9page)

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초록· 키워드

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We reported previously that the administration of Korean red ginseng water extract (KRG-WE) protected the guinea pig testis against damage induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (a potent endocrine disruptor). We also found that crude saponin from ginseng was the active ingredient responsible for this protection. Here, we examined the biological role of KRGWE in an animal model of age-induced dysfunction of spermatogenesis. Twenty-four male Sprague-Dawley (six 2-monthold and eighteen 12-month-old) rats were used. The young and old control groups received only vehicle. The ginseng saponin (GS)- and KRG-WE-treated groups received GS (40 ㎎/㎏ body weight/day) and KRG-WE (200 ㎎/㎏ body weight/day), respectively, for 4 months. The number of cells, Sertoli cell index, Johnsen’ score, and sex hormone levels decreased significantly with age. However, the administration of KRG-WE and GS markedly improved the number of germ cells, seminiferous tubular size, and Johnsen’ score in the old rats. Ginseng produced a distinct testicular histological improvement in old rats. KRG-WE and GS elevated testosterone levels, while attenuating the aberrant increase in follicle stimulating hormone and luteinizing hormone levels. Sperm kinematics evaluated by a computer-assisted sperm analyzer demonstrated improvement in the percentage of motile sperm, progressive sperm motility, and curvilinear velocity associated with sperm quality, supporting the beneficial role of red ginseng in senile spermatogenesis. Overall, the total water extract had a more potent effect than the corresponding saponin fraction. In conclusion, Korean red ginseng rejuvenated age-induced testicular dysfunction. Additionally, the total water extract was more potent than the corresponding saponin fraction.

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2012-524-004168125