지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 9 - 17 (9page)
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초록· 키워드
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Background: Alzheimer’s disease (AD) is a progressive brain disease, for which there is no effective drug therapy at present. Ginsenoside Rg1 (G-Rg1) and G-Rg2 have been reported to alleviate memory deterioration. However, the mechanism of their anti-AD effect has not yet been clearly elucidated.
Methods: Ultra performance liquid chromatography tandem MS (UPLC/MS)-based metabolomics was used to identify metabolites that are differentially expressed in the brains of AD mice with or without ginsenoside treatment. The cognitive function of mice and pathological changes in the brain were also assessed using the Morris water maze (MWM) and immunohistochemistry, respectively.
Results: The impaired cognitive function and increased hippocampal Aβ deposition in AD mice were ameliorated by G-Rg1 and G-Rg2. In addition, a total of 11 potential biomarkers that are associated with the metabolism of lysophosphatidylcholines (LPCs), hypoxanthine, and sphingolipids were identified in the brains of AD mice and their levels were partly restored after treatment with G-Rg1 and G-Rg2. G-Rg1 and G-Rg2 treatment influenced the levels of hypoxanthine, dihydrosphingosine, hexadecasphinganine, LPC C 16:0, and LPC C 18:0 in AD mice. Additionally, G-Rg1 treatment also influenced the levels of phytosphingosine, LPC C 13:0, LPC C 15:0, LPC C 18:1, and LPC C 18:3 in AD mice.
Conclusion: These results indicate that the improvements in cognitive function and morphological changes produced by G-Rg1 and G-Rg2 treatment are caused by regulation of related brain metabolic pathways. This will extend our understanding of the mechanisms involved in the effects of G-Rg1 and G-Rg2 on AD.
Methods: Ultra performance liquid chromatography tandem MS (UPLC/MS)-based metabolomics was used to identify metabolites that are differentially expressed in the brains of AD mice with or without ginsenoside treatment. The cognitive function of mice and pathological changes in the brain were also assessed using the Morris water maze (MWM) and immunohistochemistry, respectively.
Results: The impaired cognitive function and increased hippocampal Aβ deposition in AD mice were ameliorated by G-Rg1 and G-Rg2. In addition, a total of 11 potential biomarkers that are associated with the metabolism of lysophosphatidylcholines (LPCs), hypoxanthine, and sphingolipids were identified in the brains of AD mice and their levels were partly restored after treatment with G-Rg1 and G-Rg2. G-Rg1 and G-Rg2 treatment influenced the levels of hypoxanthine, dihydrosphingosine, hexadecasphinganine, LPC C 16:0, and LPC C 18:0 in AD mice. Additionally, G-Rg1 treatment also influenced the levels of phytosphingosine, LPC C 13:0, LPC C 15:0, LPC C 18:1, and LPC C 18:3 in AD mice.
Conclusion: These results indicate that the improvements in cognitive function and morphological changes produced by G-Rg1 and G-Rg2 treatment are caused by regulation of related brain metabolic pathways. This will extend our understanding of the mechanisms involved in the effects of G-Rg1 and G-Rg2 on AD.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
5. Conclusion
References
참고문헌 (45)
참고문헌 신청
[학술지(정기간행물)] - Inoue K / 2013 / Metabolic profiling of Alzheimer’s disease brains / Sci Rep 3 : 2364 ~ 2372
[학술지(정기간행물)] - Wan W / 2014 / The potential mechanisms of Abeta-receptor for advanced glycation end-products interaction disrupting tight junctions of the blood-brain barrier in Alzheimer’s disease / Int J Neurosci 124 : 75 ~ 81
[학술지(정기간행물)] - Pratico D / 2008 / Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal / Trends Pharmacol Sci 29 : 609 ~ 615
[학술지(정기간행물)] - Fang F / 2012 / Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model / Biochim Biophys Acta 1822 : 286 ~ 292
[학술지(정기간행물)] - Tan X / 2014 / Ginseng improves cognitive deficit via the RAGE/NF-kB pathway in advanced glycation end product-induced rats / J Ginseng Res 9 : 1 ~ 9
[학술지(정기간행물)] - Wan W / 2014 / The potential mechanisms of Abeta-receptor for advanced glycation end-products interaction disrupting tight junctions of the blood-brain barrier in Alzheimer’s disease / Int J Neurosci 124 : 75 ~ 81
[학술지(정기간행물)] - Pratico D / 2008 / Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal / Trends Pharmacol Sci 29 : 609 ~ 615
[학술지(정기간행물)] - Fang F / 2012 / Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model / Biochim Biophys Acta 1822 : 286 ~ 292
[학술지(정기간행물)] - Tan X / 2014 / Ginseng improves cognitive deficit via the RAGE/NF-kB pathway in advanced glycation end product-induced rats / J Ginseng Res 9 : 1 ~ 9
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UCI(KEPA) : I410-ECN-0101-2018-524-001598047