지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.3
- 수록면
- 210 - 217 (8page)
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초록· 키워드
오류제보하기
Background: Effects of the major ginsenoside Rg1 on mammalian longevity and physical vitality are rarely reported. Purpose: To examine longevity, tumor, and spontaneous locomotor activity in rats consuming Rg1.
Methods: A total of 138 Wistar rats were randomized into 2 groups: control (N ¼ 69) and Rg1 (N ¼ 69). Rg1 (0.1 mg/kg per day) were orally supplemented from 6 months of age until natural death. Spontaneous mobility was measured by video-tracking together with body composition (dual energy x-ray absorptiometry) and inflammation markers at 5, 14, 21, and 28 months of age. Results: No significant differences in longevity (control: 706 days; Rg1: 651 days, p ¼ 0.77) and tumor incidence (control: 19%; Rg1: 12%, p ¼ 0.24) were observed between the two groups. Movement distance in the control group declined significantly by ~60% at 21 months of age, together with decreased TNF-a (p ¼ 0.01) and increased IL-10 (p ¼ 0.02). However, the movement distance in the Rg1 group was maintained ~50% above the control groups (p ¼ 0.01) at 21 months of age with greater magnitudes of TNF-a decreases and IL-10 increases. Glucose, insulin, and body composition (bone, muscle and fat percentages) were similar for both groups during the entire observation period.
Conclusion: The results of the study suggest a delay age-dependent decline in physical vitality during late life by lifelong Rg1 consumption. This improvement is associated with inflammatory modulation. Significant effects of Rg1 on longevity and tumorigenesis were not observed.
Methods: A total of 138 Wistar rats were randomized into 2 groups: control (N ¼ 69) and Rg1 (N ¼ 69). Rg1 (0.1 mg/kg per day) were orally supplemented from 6 months of age until natural death. Spontaneous mobility was measured by video-tracking together with body composition (dual energy x-ray absorptiometry) and inflammation markers at 5, 14, 21, and 28 months of age. Results: No significant differences in longevity (control: 706 days; Rg1: 651 days, p ¼ 0.77) and tumor incidence (control: 19%; Rg1: 12%, p ¼ 0.24) were observed between the two groups. Movement distance in the control group declined significantly by ~60% at 21 months of age, together with decreased TNF-a (p ¼ 0.01) and increased IL-10 (p ¼ 0.02). However, the movement distance in the Rg1 group was maintained ~50% above the control groups (p ¼ 0.01) at 21 months of age with greater magnitudes of TNF-a decreases and IL-10 increases. Glucose, insulin, and body composition (bone, muscle and fat percentages) were similar for both groups during the entire observation period.
Conclusion: The results of the study suggest a delay age-dependent decline in physical vitality during late life by lifelong Rg1 consumption. This improvement is associated with inflammatory modulation. Significant effects of Rg1 on longevity and tumorigenesis were not observed.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
4. Conclusion
References
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UCI(KEPA) : I410-ECN-0101-2023-524-001465859