지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 580 - 588 (9page)
이용수
초록· 키워드
오류제보하기
Background: Ginsenoside Rg1 has been shown to clear senescence-associated beta-galactosidase (SA-β-gal) in cultured cells. It remains unknown whether Rg1 can influence SA-β-gal in exercising human skeletal muscle.
Methods: To examine SA-β-gal change, 12 young men (age 21±0.2 years) were enrolled in a randomized double-blind placebo controlled crossover study, under two occasions: placebo (PLA) and Rg1 (5 mg) supplementations 1 h prior to a high-intensity cycling (70% VO<SUB>2max</SUB>). Muscle samples were collected by multiple biopsies before and after cycling exercise (0 h and 3 h). To avoid potential effect of muscle biopsy on performance assessment, cycling time to exhaustion test (80% VO<SUB>2max</SUB>) was conducted on another 12 participants (age 23±0.5 years) with the same experimental design.
Results: No changes of SA-β-gal were observed after cycling in the PLA trial. On the contrary, nine of the 12 participants showed complete elimination of SA-β-gal in exercised muscle after cycling in the Rg1 trial (p < 0.05). Increases in apoptotic DNA fragmentation (PLA: +87% vs. Rg1: +133%, p < 0.05) and CD68+(PLA:+78% vs. Rg1:+121%, p=0.17) occurred immediately after cycling in both trials. During the 3-h recovery, reverses in apoptotic nuclei content (PLA:+5% vs. Rg1:-32%, p<0.01) and increases in inducible nitrate oxide synthase and interleukin 6 mRNA levels of exercised muscle were observed only in the Rg1 trial (p < 0.01).
Conclusion: Rg1 supplementation effectively eliminates senescent cells in exercising human skeletal muscle and improves high-intensity endurance performance.
Methods: To examine SA-β-gal change, 12 young men (age 21±0.2 years) were enrolled in a randomized double-blind placebo controlled crossover study, under two occasions: placebo (PLA) and Rg1 (5 mg) supplementations 1 h prior to a high-intensity cycling (70% VO<SUB>2max</SUB>). Muscle samples were collected by multiple biopsies before and after cycling exercise (0 h and 3 h). To avoid potential effect of muscle biopsy on performance assessment, cycling time to exhaustion test (80% VO<SUB>2max</SUB>) was conducted on another 12 participants (age 23±0.5 years) with the same experimental design.
Results: No changes of SA-β-gal were observed after cycling in the PLA trial. On the contrary, nine of the 12 participants showed complete elimination of SA-β-gal in exercised muscle after cycling in the Rg1 trial (p < 0.05). Increases in apoptotic DNA fragmentation (PLA: +87% vs. Rg1: +133%, p < 0.05) and CD68+(PLA:+78% vs. Rg1:+121%, p=0.17) occurred immediately after cycling in both trials. During the 3-h recovery, reverses in apoptotic nuclei content (PLA:+5% vs. Rg1:-32%, p<0.01) and increases in inducible nitrate oxide synthase and interleukin 6 mRNA levels of exercised muscle were observed only in the Rg1 trial (p < 0.01).
Conclusion: Rg1 supplementation effectively eliminates senescent cells in exercising human skeletal muscle and improves high-intensity endurance performance.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
5. Conclusion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Ginsenoside Rg1 augments oxidative metabolism and anabolic response of skeletal muscle in mice
Journal of Ginseng Research
2019 .06
-
Proteomic analyses reveal that ginsenoside Rg3(S) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin
Journal of Ginseng Research
2020 .01
-
Ginsenoside Rg5 promotes muscle regeneration via p38MAPK and Akt/mTOR signaling
Journal of Ginseng Research
2023 .11
-
Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1
Journal of Ginseng Research
2023 .03
-
A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer’s disease
Journal of Ginseng Research
2016 .01
-
Ginsenoside Rg1 enhances the healing of injured tendon in achilles tendinitis through the activation of IGF1R signaling mediated by oestrogen receptor
Journal of Ginseng Research
2022 .07
-
Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling
Journal of Ginseng Research
2020 .03
-
Ginsenoside Rg1 suppresses early stage of adipocyte development via activation of C/EBP homologous protein-10 in 3T3-L1 and attenuates fat accumulation in high fat diet-induced obese zebrafish
Journal of Ginseng Research
2017 .01
-
Ginsenoside Rg3 suppresses mast cellemediated allergic inflammation via mitogen-activated protein kinase signaling pathway
Journal of Ginseng Research
2019 .04
-
Ginsenoside Rg1 Epigenetically Modulates Smad7 Expression in Liver Fibrosis via MicroRNA-152
Journal of Ginseng Research
2023 .07
-
초음파 처리에 의한 인삼꽃대 엑스의 진세노사이드 성분 변화
생약학회지(Korean Journal of Pharmacognosy)
2016 .03
-
Ginsenoside Rg3 attenuates skin disorders via down-regulation of MDM2/HIF1a signaling pathway
Journal of Ginseng Research
2021 .09
-
Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production
Journal of Ginseng Research
2022 .01
-
Global analysis of ginsenoside Rg1 protective effects in b-amyloid-treated neuronal cells
Journal of Ginseng Research
2017 .10
-
Enhanced Rg3 negatively regulates Th1 cell responses
Journal of Ginseng Research
2019 .01
-
A new role for the ginsenoside RG3 in antiaging via mitochondria function in ultraviolet-irradiated human dermal fibroblasts
Journal of Ginseng Research
2019 .06
-
Integration of virtual screening and proteomics reveals potential targets and pathways for ginsenoside Rg₁ against myocardial ischemia
Journal of Ginseng Research
2024 .07
-
Ginsenoside Rg3 promotes inflammation resolution through M2 macrophage polarization
Journal of Ginseng Research
2018 .01
-
Kinetic study for the optimization of ginsenoside Rg3 production by heat treatment of ginsenoside Rb1
Journal of Ginseng Research
2015 .10
-
Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng
Journal of Ginseng Research
2018 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2020-524-000504859