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논문 기본 정보

자료유형
학술저널
저자정보
손현진 (동아대학교) 이미영 (부산대학교병원) 은영덕 (부산대학교병원) 박원서 (Busan Center for Infectious Disease Control and Prevention Pusan National University Hospital) 박경희 (Busan Center for Infectious Disease Control and Prevention Pusan National University Hospita) 권소라 (Busan Center for Infectious Disease Control and Prevention Pusan National University Hospital) 김승진 (Korea Disease Control and Prevention Agency) 김창훈 (부산대학교 의과대학 예방의학교실)
저널정보
한국역학회 Epidemiology and Health Epidemiology and Health Vol.44
발행연도
2022.1
수록면
1 - 8 (8page)
DOI
10.4178/epih.e2022003

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OBJECTIVES: In July 2019, there were multiple reports on patients with hepatitis A among the visitors of a restaurant in Busan. The current study presents the results of an epidemiological investigation and outlines the supplementary measures that would help with hepatitis A control. METHODS: A cohort study was conducted for all 2,865 customers who visited restaurant A from June to July. Using a standardized questionnaire, participants reported the presence of hepatitis A symptoms and whether they had consumed any of 19 food items. As for participants who had visited public health centers, their specimens were collected. RESULTS: From the study cohort, 155 participants (5.4%) had confirmed hepatitis A. The epidemic curve was unimodal, and the median number of days from the restaurant visit to symptom onset was 31 days. A genotype analysis indicated that 89 of 90 tested patients had hepatitis A virus (HAV) genotype 1A. The results of a multivariate logistic regression analysis indicated that the ingestion of salted clams increased the risk of hepatitis A by 68.12 times (95% confidence interval [CI], 9.22 to 510.87). In an unopened package of salted clams found and secured through traceback investigation, HAV genotype 1A was detected. CONCLUSIONS: To prevent people from ingesting uncooked clams, there needs to be more efforts to publicize the dangers of uncooked clams; the food sampling test standards for salted clams should also be expanded. Furthermore, a laboratory surveillance system based on molecular genetics should be established to detect outbreaks earlier.

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