지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 1,029 - 1,034 (6page)
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Curcumin (diferuloyl methane), originated rhizomes of Curcuma longa L. has been suggested as an antiinflammatory and anti-carcinogenic agent. In the present study, modulation of cytotoxic effects of curcumin on HeLa cells by different types of antioxidants was investigated. Cytotoxic effects of curcumin were significantly enhanced in the presence of superoxide dismutase (SOD) by decreasing IC<sub>50</sub> to 15.4 from 26.0 μM after 24 hr incubation; the activity was not altered by catalase. The effect of curcumin was significantly less pronounced in the presence of 4 mM N-acetylcysteine (NAC). Low concentration (<1 mM) of NAC, however, increased the efficacy of curcumin. Cysteine and β-mercaptoethanol that have a thiol group, showed the similar biphasic patterns as NAC for modulating curcumin cytotoxicity, which was, however, constantly enhanced by ascorbic acid, a non-thiol antioxidant. In the presence of SOD, ascorbic acid, and 0.5 mM NAC, cellular levels of curcumin were significantly increased by 31-66%, whereas 4 mM NAC decreased the level. The present results indicate that thiol reducing agents showed a biphasic effect in modulating cytotoxicity of curcumin; it is likely that their thiol group is reactive with curcumin especially at high concentrations.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Ammon HP / 1992 / A potent inhibitor of leukotriene B4 formation in ratperitoneal polymorphonuclear neutrophils
2. [학술지(정기간행물)] - / 2006 / Antimicrobial properties of turmeric(Curcuma longa L.) rhizome-derived αγ-turmerone and curcumin 15 : 559 ~ 563
3. [학술지(정기간행물)] - / 2005 / Cancer preventive role of selected dietary factors 42 : 15 ~ 24
4. [학술지(정기간행물)] - / 2007 / Cancer chemopreventive effects of curcumin 595 : 149 ~ 172
5. [학술지(정기간행물)] - / 1993 / Reddy BS. Inhibition by dietary curcumin ofazoxymethane-induced ornithine decarboxylase and aberrant crypt fociformation in the rat colon. Carcinogenesis 14 : 2219 ~ 2225
2. [학술지(정기간행물)] - / 2006 / Antimicrobial properties of turmeric(Curcuma longa L.) rhizome-derived αγ-turmerone and curcumin 15 : 559 ~ 563
3. [학술지(정기간행물)] - / 2005 / Cancer preventive role of selected dietary factors 42 : 15 ~ 24
4. [학술지(정기간행물)] - / 2007 / Cancer chemopreventive effects of curcumin 595 : 149 ~ 172
5. [학술지(정기간행물)] - / 1993 / Reddy BS. Inhibition by dietary curcumin ofazoxymethane-induced ornithine decarboxylase and aberrant crypt fociformation in the rat colon. Carcinogenesis 14 : 2219 ~ 2225
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UCI(KEPA) : I410-ECN-0101-2013-573-001010532