지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 241 - 251 (11page)
이용수
초록· 키워드
오류제보하기
Bone marrow-derived mesenchymal stem cells (MSCs) have immunomodulatory properties and can suppress exaggerated pro-inflammatory immune responses. Although the exact mechanisms remain unclear, a variety of soluble factors are known to contribute to MSC-mediated immunosuppression. However, functional redundancy in the immunosuppressive properties of MSCs indicates that other uncharacterized factors could be involved. Galectin-9, a member of the β-galactoside binding galectin family, has emerged as an important regulator of innate and adaptive immunity. We examined whether galectin-9 contributes to MSC-mediated immunosuppression. Galectin-9 was strongly induced and secreted from human MSCs upon stimulation with pro-inflammatory cytokines. An in vitro immunosuppression assay using a knockdown approach revealed that galectin-9-deficient MSCs do not exert immunosuppressive activity. We also provided evidence that galectin-9 may contribute to MSC-mediated immunosuppression by binding to its receptor, TIM-3, expressed on activated lymphocytes, leading to apoptotic cell death of activated lymphocytes. Taken together, our findings demonstrate that galectin-9 is involved in MSC-mediated immunosuppression and represents a potential therapeutic factor for the treatment of inflammatory diseases.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (63)
참고문헌 신청
[학술지(정기간행물)] - da Silva, M. L. / 2006 / Mesenchymal stem cells reside in virtually all post-natal organs tissues / J. Cell Sci 119 : 2204 ~ 2213
[학술지(정기간행물)] - Zuk, P. A. / 2002 / Human adipose tissue is a source of multipotent stem cells / Mol. Biol. Cell 13 : 4279 ~ 4295
[학술지(정기간행물)] - Pittenger, M. F. / 1999 / Multilineage potential of adult human mesenchymal stem cells / Science 284 : 143 ~ 147
[학술지(정기간행물)] - Uccelli, A. / 2008 / Mesenchymal stem cells in health disease / Nat. Rev. Immunol 8 : 726 ~ 736
[학술지(정기간행물)] - Le, B. K. / 2008 / Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease : a phase II study / Lancet 371 : 1579 ~ 1586
[학술지(정기간행물)] - Zuk, P. A. / 2002 / Human adipose tissue is a source of multipotent stem cells / Mol. Biol. Cell 13 : 4279 ~ 4295
[학술지(정기간행물)] - Pittenger, M. F. / 1999 / Multilineage potential of adult human mesenchymal stem cells / Science 284 : 143 ~ 147
[학술지(정기간행물)] - Uccelli, A. / 2008 / Mesenchymal stem cells in health disease / Nat. Rev. Immunol 8 : 726 ~ 736
[학술지(정기간행물)] - Le, B. K. / 2008 / Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease : a phase II study / Lancet 371 : 1579 ~ 1586
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UCI(KEPA) : I410-ECN-0101-2016-511-002009688