지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.11
- 수록면
- 317 - 325 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Mesenchymal stem cells (MSCs) are surfacing as a new method of treatment for various diseases that have poor outcome with drug treatments. In this study, we investigated the effects of MSCs in a murine intestinal inflammation model mimicking human Crohn’s disease (CD) using 2,4,5-trinitrobenzene sulfonic acid (TNBS).
Methods: Colitis was induced by rectal administration of 2 mg of TNBS in 35% ethanol as experimental group compared to control group. Histological changes, surface molecules of T and B cells of the spleen and blood, and cytokine production (IFN-γ, TNF-α, IL-4, IL-6, IL-10, and IL-12) were determined among 3 groups comprised of control group, TNBS group and TNBS/MSC group.
Results: In the mice treated with MSCs, there was a decrease in the wasting disease process and inflammatory histopathological changes. There was also a decrease in pro-inflammatory T-helper 1 (Th1) cytokines IFN-γ and IL-12 and T-helper 2 (Th2) cytokine IL-4. Anti-inflammatory cytokine IL-10 increased in mice treated with MSCs compared to colitic mice. The blood CD4?CD25? T-regulatory cells also increased and splenic CD19 B-cells decreased.
Conclusion: The results of this study suggest that MSCs may have a therapeutic effect in controlling the Th1 and Th2 mediated immune response in patients with CD and aid in tissue regeneration.
Methods: Colitis was induced by rectal administration of 2 mg of TNBS in 35% ethanol as experimental group compared to control group. Histological changes, surface molecules of T and B cells of the spleen and blood, and cytokine production (IFN-γ, TNF-α, IL-4, IL-6, IL-10, and IL-12) were determined among 3 groups comprised of control group, TNBS group and TNBS/MSC group.
Results: In the mice treated with MSCs, there was a decrease in the wasting disease process and inflammatory histopathological changes. There was also a decrease in pro-inflammatory T-helper 1 (Th1) cytokines IFN-γ and IL-12 and T-helper 2 (Th2) cytokine IL-4. Anti-inflammatory cytokine IL-10 increased in mice treated with MSCs compared to colitic mice. The blood CD4?CD25? T-regulatory cells also increased and splenic CD19 B-cells decreased.
Conclusion: The results of this study suggest that MSCs may have a therapeutic effect in controlling the Th1 and Th2 mediated immune response in patients with CD and aid in tissue regeneration.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Podolsky DK / 1991 / Inflammatory bowel disease (1) / N Engl J Med 325 : 928 ~ 937
2. [학술지(정기간행물)] - Fiocchi C / 1998 / Inflammatory bowel disease: etiology and pathogenesis / Gastroenterology 115 : 182 ~ 205
3. [학술지(정기간행물)] - MacDonald TT / 2000 / Recent developments in the immunology of inflammatory bowel disease / Scand J Immunol 51 : 2 ~ 9
4. [학술지(정기간행물)] - Shanahan F / 2001 / Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics / Gastroenterology 120 : 622 ~ 635
5. [학술지(정기간행물)] - Geboes K / 1994 / From inflammation to lesion / Acta Gastroenterol Belg 57 : 273 ~ 284
2. [학술지(정기간행물)] - Fiocchi C / 1998 / Inflammatory bowel disease: etiology and pathogenesis / Gastroenterology 115 : 182 ~ 205
3. [학술지(정기간행물)] - MacDonald TT / 2000 / Recent developments in the immunology of inflammatory bowel disease / Scand J Immunol 51 : 2 ~ 9
4. [학술지(정기간행물)] - Shanahan F / 2001 / Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics / Gastroenterology 120 : 622 ~ 635
5. [학술지(정기간행물)] - Geboes K / 1994 / From inflammation to lesion / Acta Gastroenterol Belg 57 : 273 ~ 284
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